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Codevelopment of AD...
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Kuja-Halkola, RalfKarolinska Institutet
(author)
Codevelopment of ADHD and externalizing behavior from childhood to adulthood
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2014-10-10
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Stockholm :Wiley-Blackwell,2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-54615
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ISSN:0021-9630
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10616/45052hdl
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-54615URI
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https://doi.org/10.1111/jcpp.12340DOI
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http://hdl.handle.net/10616/45052URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:131302453URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies:Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) 340-2013-5867National Institute of Child Health and Human Development HD061817
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BACKGROUND: Attention-Deficit/Hyperactivity Disorder (ADHD) frequently co-occurs with externalizing disorders, but a clear understanding of the etiologic underpinnings is hampered by the limited understanding of the codevelopment of the traits from childhood into early adulthood.METHODS: Using a birth cohort of 2600 twins, the Swedish Twin study of Child and Adolescent Development study, assessed at ages 8-9, 13-14, 16-17, and 19-20, we investigated the codevelopment of ADHD and externalizing behavior from childhood to adulthood. The analyses examined ADHD-like and externalizing traits, as rated by twins and their parents using the Attention Problems scale and Externalizing scale of the Child Behavior Checklist, and estimated cross-lagged effects (one trait at one time-point predicting the other at the next). The covariation between the traits were decomposed into stable (effects carried over from the prior time-points) and innovative (new effects for each time-point) sources; each source was further decomposed into additive genetics, shared and nonshared environment.RESULTS: The analysis suggested that externalizing traits in middle childhood (age 8-9) predicted ADHD-like traits in early adolescence (age 13-14), whereas the reverse association was nonsignificant. In contrast, ADHD-like traits in lateadolescence (age 16-17) predicted externalizing traits in early adulthood (age 19-20). The correlation between ADHD-like and externalizing traits increased over time. At all time-points, innovative sources contributed substantially to maintained comorbidity. Genetic effects explained 67% of the covariation at each time-point; importantly, nearly 50% of these effects were innovative.CONCLUSIONS: This study challenges the belief that ADHD generally precedes externalizing behaviors; rather, change in the etiologic factors across the development is the rule. The effects were due to both new genetic and environmental factors emerging up to young adulthood. Clinicians and researchers needs to consider complex etiologic and developmental models for the comorbidity between ADHD and externalizing behaviors.
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Lichtenstein, PaulKarolinska Institutet
(author)
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D'Onofrio, Brian MDepartment of Psychological and Brain Sciences, Indiana University, Bloomington IN, USA
(author)
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Larsson, Henrik,1975-Karolinska Institutet(Swepub:oru)hiln
(author)
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Karolinska InstitutetDepartment of Psychological and Brain Sciences, Indiana University, Bloomington IN, USA
(creator_code:org_t)
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Karolinska Institutet
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Karolinska Institutet
Related titles
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In:Journal of Child Psychology and PsychiatryStockholm : Wiley-Blackwell56:6, s. 640-6470021-96301469-7610
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