A Genetically Informed Study of the Associations Between Maternal Age at Childbearing and Adverse Perinatal Outcomes

Sujan, Ayesha C.Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA (författare)

Funding Agencies:National Science Foundation Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM)National Institute of Child Health and Human Development
We examined associations of maternal age at childbearing (MAC) with gestational age and fetal growth (i.e., birth weight adjusting for gestational age), using two genetically informed designs (cousin and sibling comparisons) and data from two cohorts, a population-based Swedish sample and a nationally representative United States sample. We also conducted sensitivity analyses to test limitations of the designs. The findings were consistent across samples and suggested that, associations observed in the population between younger MAC and shorter gestational age were confounded by shared familial factors; however, associations of advanced MAC with shorter gestational age remained robust after accounting for shared familial factors. In contrast to the gestational age findings, neither early nor advanced MAC was associated with lower fetal growth after accounting for shared familial factors. Given certain assumptions, these findings provide support for a causal association between advanced MAC and shorter gestational age. The results also suggest that there are not causal associations between early MAC and shorter gestational age, between early MAC and lower fetal growth, and between advanced MAC and lower fetal growth.

Rickert, Martin E.Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA (författare)
Class, Quetzal A.Karolinska Institutet (författare)
Coyne, Claire A.Ann and Robert H. Lurie Children’s Hospital, Chicago, USA (författare)
Lichtenstein, PaulKarolinska Institutet (författare)
Almqvist, CatarinaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden (författare)
Larsson, Henrik,1975-Karolinska Institutet(Swepub:oru)hiln (författare)
Sjölander, ArvidKarolinska Institutet (författare)
Lahey, Benjamin B.Department of Public Health Sciences, University of Chicago, Chicago, USA (författare)
van Hulle, CarolWaisman Center, University of Wisconsin, Madison, USA (författare)
Waldman, IrwinDepartment of Psychology, Emory University, Atlanta, USA (författare)
Öberg, A. SaraDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA (författare)
D'Onofrio, Brian M.Karolinska Institutet (författare)
Karolinska InstitutetDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, USA (creator_code:org_t)
Karolinska Institutet
Karolinska Institutet

Ingår i:Behavior GeneticsNew York, USA : Springer46:3, s. 431-4560001-82441573-3297

Av författaren/redakt...: Sujan, Ayesha C.; Rickert, Martin ...; Class, Quetzal A ...; Coyne, Claire A.; Lichtenstein, Pa ...; Almqvist, Catari ...; visa fler...; Larsson, Henrik, ...; Sjölander, Arvid; Lahey, Benjamin ...; van Hulle, Carol; Waldman, Irwin; Öberg, A. Sara; D'Onofrio, Brian ...; visa färre...

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