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  • Borg, J.Karolinska Institutet (författare)

Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2015-10-06
  • London, United Kingdom :Nature Publishing Group,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-54640
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-54640URI
  • https://doi.org/10.1038/mp.2015.147DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440731URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133998768URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136982675URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The dopamine (DA) and serotonin (5-HT) neurotransmission systems are of fundamental importance for normal brain function and serve as targets for treatment of major neuropsychiatric disorders. Despite central interest for these neurotransmission systems in psychiatry research, little is known about the regulation of receptor and transporter density levels. This lack of knowledge obscures interpretation of differences in protein availability reported in psychiatric patients. In this study, we used positron emission tomography (PET) in a twin design to estimate the relative contribution of genetic and environmental factors, respectively, on dopaminergic and serotonergic markers in the living human brain. Eleven monozygotic and 10 dizygotic healthy male twin pairs were examined with PET and [(11)C]raclopride binding to the D2- and D3-dopamine receptor and [(11)C]WAY100635 binding to the serotonin 5-HT1A receptor. Heritability, shared environmental effects and individual-specific non-shared effects were estimated for regional D2/3 and 5-HT1A receptor availability in projection areas. We found a major contribution of genetic factors (0.67) on individual variability in striatal D2/3 receptor binding and a major contribution of environmental factors (pairwise shared and unique individual; 0.70-0.75) on neocortical 5-HT1A receptor binding. Our findings indicate that individual variation in neuroreceptor availability in the adult brain is the end point of a nature-nurture interplay, and call for increased efforts to identify not only the genetic but also the environmental factors that influence neurotransmission in health and disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Cervenka, SimonKarolinska Institutet(Swepub:uu)simce160 (author)
  • Kuja-Halkola, RKarolinska Institutet (author)
  • Matheson, G. J.Karolinska Institutet (author)
  • Jönsson, E. G.Karolinska Institutet (author)
  • Lichtenstein, P.Karolinska Institutet (author)
  • Henningsson, S.Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark,Copenhagen Univ Hosp, Danish Res Ctr Magnet Resonance, Hvidovre, Denmark. (author)
  • Ichimiya, T.Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan,Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden.;Nippon Med Sch, Dept Neuropsychiat, Tokyo, Japan. (author)
  • Larsson, Henrik,1975-Karolinska Institutet(Swepub:oru)hiln (author)
  • Stenkrona, P.Karolinska Institutet (author)
  • Halldin, C.Karolinska Institutet (author)
  • Farde, L.Karolinska Institutet (author)
  • Karolinska InstitutetDanish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark (creator_code:org_t)

Related titles

  • In:Molecular PsychiatryLondon, United Kingdom : Nature Publishing Group51, s. 879-8791359-41841476-5578
  • In:INTERNATIONAL JOURNAL OF PSYCHOLOGYLondon, United Kingdom : Nature Publishing Group51, s. 879-8790020-7594

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