Can probiotics modulate human disease by impacting intestinal barrier function?

Sökning: WFRF:(Jerry D) > Can probiotics modu...

Bron, Peter A.NIZO Food Research, Ede, The Netherlands; BE-Basic Foundation, The Netherlands, Delft, The Netherlands (författare)

Funding Agencies:ILSI Europe Probiotic Task ForceFNRSFrench Cancer Research Association (ARC)Fonds de la Recherche Scientifique - FNRS WELBIO-CR-2012S-02RFunds InBev-Baillet LatourERC Starting GrantEuropean Research Council, Starting grant 336452-ENIGMO
Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major aetiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis, irritable bowel syndrome and inflammatory bowel disease. The notion that specific probiotic bacterial strains can affect barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are used to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues and categorises the lines of evidence available in literature for the role of probiotics in epithelial integrity and, consequently, their beneficial effect for the reduction of gastrointestinal disease symptoms.

Kleerebezem, MichielHost Microbe Interactomics Group, Wageningen University, Wageningen, The Netherlands (författare)
Brummer, Robert-Jan,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län(Swepub:oru)rnbr (författare)
Cani, Patrice D.Metabolism and Nutrition Research Group, WELBIO – Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium (författare)
Mercenier, AnnickNutrition and Health Research, Nestlé Research Center, Lausanne, Switzerland (författare)
MacDonald, Thomas T.Barts and The London school of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK (författare)
Garcia-Ródenas, Clara LNutrition and Health Research, Nestlé Research Center, Lausanne, Switzerland (författare)
Wells, Jerry M.Host Microbe Interactomics Group, Wageningen University, Wageningen, The Netherlands (författare)
NIZO Food Research, Ede, The Netherlands; BE-Basic Foundation, The Netherlands, Delft, The NetherlandsHost Microbe Interactomics Group, Wageningen University, Wageningen, The Netherlands (creator_code:org_t)

Ingår i:British Journal of NutritionCambridge, United Kingdom : Cambridge University Press117:1, s. 93-1070007-11451475-2662

Av författaren/redakt...: Bron, Peter A.; Kleerebezem, Mic ...; Brummer, Robert- ...; Cani, Patrice D.; Mercenier, Annic ...; MacDonald, Thoma ...; visa fler...; Garcia-Ródenas, ...; Wells, Jerry M.; visa färre...

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