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Fecal stream divers...
Fecal stream diversion and mucosal cytokine levels in collagenous colitis : A case report
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- Daferera, Niki (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Hälsouniversitetet,Region Östergötland, Magtarmmedicinska kliniken
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- Kumawat, Ashok Kumar, 1982- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,University of Örebro, Sweden
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- Hultgren-Hörnquist, Elisabeth, 1965- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,University of Örebro, Sweden
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- Ignatova, Simone (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet,Region Östergötland, Klinisk patologi och klinisk genetik
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- Ström, Magnus (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken
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- Münch, Andreas (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken
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(creator_code:org_t)
- Pleasanton, USA : Baishideng Publishing Group Inc. 2015
- 2015
- Engelska.
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Ingår i: World Journal of Gastroenterology. - Pleasanton, USA : Baishideng Publishing Group Inc.. - 1007-9327 .- 2219-2840. ; 21:19, s. 6065-6071
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- In this case report, we examined the levels of cytokines expressed before and during fecal stream diversion and after intestinal continuity was restored in a patient with collagenous colitis. We report the case of a 46-year-old woman with chronic, active collagenous colitis who either failed to achieve clinical remission or experienced adverse effects with the following drugs: loperamide, cholestyramine, budesonide, methotrexate and adalimumab. Due to the intractable nature of the disease and because the patient was having up to 15 watery bowel movements per day, she underwent a temporary ileostomy. Colonic biopsies were analyzed for mucosal cytokine protein levels before and during fecal stream diversion and after intestinal continuity was restored. Mucosal protein levels of interleukin (IL)-1β, IL-2, IL-6, IL-12, IL-17 A, IL-23, TNF, IFN-γ, IL-4, IL-5, IL-10 and IL-13 were all higher during active disease and decreased to non-detectable or considerably lower levels during fecal stream diversion. One month after the restoration of bowel continuity, when the patient experienced a relapse of symptoms, IL-2, IL-23 and IL-21 levels were again increased. Our results indicate that fecal stream diversion in this patient suppressed the levels of all cytokines analyzed in colonic biopsies. With the recurrence of clinical symptoms and histological changes after bowel reconstruction, the levels of primarily proinflammatory cytokines increased. Our findings support the hypothesis that a luminal factor triggers the inflammation observed in collagenous colitis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Immunologi
- Immunology
- Microscopic colitis; Collagenous colitis; Luminex; Mucosal cytokines; Fecal stream diversion
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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