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Defining venous thr...
Defining venous thromboembolism and measuring its incidence using Swedish health registries : a nationwide pregnancy cohort study
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- Sultan, Alyshah Abdul (författare)
- Div Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England; Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden; Queens Med Ctr, Nottingham Digest Dis Biomed Res Unit, Univ Nottingham, Nottingham, England
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- West, Joe (författare)
- Div Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England
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- Stephansson, Olof (författare)
- Karolinska Institutet
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- Grainge, Matthew J. (författare)
- Div Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England
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- Tata, Laila J. (författare)
- Div Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England
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- Fleming, Kate M. (författare)
- Div Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England
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- Humes, David (författare)
- Div Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institutet,Region Örebro län,Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2015-11-11
- 2015
- Engelska.
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Ingår i: BMJ Open. - London, United Kingdom : BMJ Publishing Group Ltd. - 2044-6055. ; 5:11
- Relaterad länk:
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https://doi.org/10.1...
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https://bmjopen.bmj....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objective: To accurately define venous thromboembolism (VTE) in the routinely collected Swedish health registers and quantify its incidence in and around pregnancy. Study design: Cohort study using data from the Swedish Medical Birth Registry (MBR) linked to the National Patient Registry (NPR) and the Swedish Prescribed Drug Register (PDR). Setting: Secondary care centres, Sweden. Participant: 509 198 women aged 15-44 years who had one or more pregnancies resulting in a live birth or stillbirth between 2005 and 2011. Main outcome measure: To estimate the incidence rate (IR) of VTE in and around pregnancy using various VTE definitions allowing direct comparison with other countries. Results: The rate of VTE varied based on the VTE definition. We found that 43% of cases first recorded as outpatient were not accompanied by anticoagulant prescriptions, whereas this proportion was much lower than those cases first recorded in the inpatient register (9%). Using our most inclusive VTE definition, we observed higher rates of VTE compared with previously published data using similar methodology. These reduced by 31% (IR=142/100 000 person-years; 95% CI 132 to 153) and 22% (IR=331/100 000 person-years; 95% CI 304 to 361) during the antepartum and postpartum periods, respectively, using a restrictive VTE definition that required anticoagulant prescriptions associated with diagnosis, which were more in line with the existing literature. Conclusions: We found that including VTE codes without treatment confirmation risks the inclusion of false-positive cases. When defining VTE using the NPR, anticoagulant prescription information should therefore be considered particularly for cases recorded in an outpatient setting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
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