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Implications of Differential Age Distribution of Disease-Associated Meningococcal Lineages for Vaccine Development

Brehony, Carina (författare)
Dept Zool, Univ Oxford, Oxford, England.
Trotter, Caroline L. (författare)
Dept Vet Med, Univ Cambridge, Cambridge, England
Ramsay, Mary E. (författare)
Publ Hlth England, London, England
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Chandra, Manosree (författare)
Publ Hlth England, London, England
Jolley, Keith A. (författare)
Dept Zool, Univ Oxford, Oxford, England
van der Ende, Arie (författare)
Dept Med Microbiol, Netherlands Reference Lab Bacterial Meningitis, Acad Med Ctr, Univ Amsterdam, Amsterdam, Netherlands
Carion, Francoise (författare)
Meningococcal Reference Lab, Sci Inst Publ Hlth, Brussels, Belgium
Berthelsen, Lene (författare)
Neisseria & Streptococcus Reference Lab, Statens Serum Inst, Copenhagen, Denmark
Hoffmann, Steen (författare)
Neisseria & Streptococcus Reference Lab, Statens Serum Inst, Copenhagen, Denmark
Hardardottir, Hjordis (författare)
Dept Microbiol, Landspitali Univ Hosp, Reykjavik, Iceland
Vazquez, Julio A. (författare)
Meningococcal Reference Lab, Madrid, Spain
Murphy, Karen (författare)
Irish Meningococcal & Meningitis Reference Lab, Dublin, Ireland
Toropainen, Maija (författare)
Natl Inst Hlth & Welf, Helsinki, Finland
Canica, Manuela (författare)
Dept Infect Dis, Lab Antimicrobial Resistance, Natl Inst Hlth Dr Ricardo Jorge, Lisbon, Portugal
Ferreira, Eugenia (författare)
Dept Infect Dis, Lab Antimicrobial Resistance, Natl Inst Hlth Dr Ricardo Jorge, Lisbon, Portugal
Diggle, Mathew (författare)
Scottish Haemophilus Legionella Meningococcus & P, Glasgow, UK
Edwards, Giles F. (författare)
Scottish Haemophilus Legionella Meningococcus & P, Glasgow, UK
Taha, Muhamed-Kheir (författare)
Inst Pasteur, Natl Reference Ctr Meningococci, Institut Pasteur, Paris, France
Stefanelli, Paola (författare)
Dept Infect Parasit & Immune Mediated Dis, Ist Super Sanita, Rome, Italy
Kriz, Paula (författare)
Natl Reference Lab Meningococcal Infect, Natl Inst Publ Hlth, Prague, Czech Republic
Gray, Steve J. (författare)
Meningococcal Reference Unit, Manchester Royal Infirm, Manchester, England
Fox, Andrew J. (författare)
Meningococcal Reference Unit, Manchester Royal Infirm, Manchester, England
Jacobsson, Susanne, 1974- (författare)
Region Örebro län,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden
Claus, Heike (författare)
Inst Hyg & Mikrobiol, Wurzburg, Germany
Vogel, Ulrich (författare)
Inst Hyg & Mikrobiol, Wurzburg, Germany
Tzanakaki, Georgina (författare)
Natl Meningococcal Reference Lab, Natl Sch Publ Hlth, Athens, Greece
Heuberger, Sigrid (författare)
Natl Reference Ctr Meningococci, Inst Med Microbiol & Hyg, Graz, Austria
Caugant, Dominique A. (författare)
Dept Bacteriol & Immunol, Norwegian Inst Publ Hlth, Oslo, Norway
Frosch, Matthias (författare)
Inst Hyg & Mikrobiol, Wurzburg, Germany
Maiden, Martin C. J. (författare)
Dept Zool, Univ Oxford, Oxford, England
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Dept Zool, Univ Oxford, Oxford, England Dept Vet Med, Univ Cambridge, Cambridge, England (creator_code:org_t)
American Society for Microbiology, 2014
2014
Engelska.
Ingår i: Clinical and Vaccine Immunology. - : American Society for Microbiology. - 1556-6811 .- 1556-679X. ; 21:6, s. 847-853
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • New vaccines targeting meningococci expressing serogroup B polysaccharide have been developed, with some being licensed in Europe. Coverage depends on the distribution of disease-associated genotypes, which may vary by age. It is well established that a small number of hyperinvasive lineages account for most disease, and these lineages are associated with particular antigens, including vaccine candidates. A collection of 4,048 representative meningococcal disease isolates from 18 European countries, collected over a 3-year period, were characterized by multilocus sequence typing (MLST). Age data were available for 3,147 isolates. The proportions of hyperinvasive lineages, identified as particular clonal complexes (ccs) by MLST, differed among age groups. Subjects <1 year of age experienced lower risk of sequence type 11 (ST-11) cc, ST-32 cc, and ST-269 cc disease and higher risk of disease due to unassigned STs, 1- to 4-year-olds experienced lower risk of ST-11 cc and ST-32 cc disease, 5- to 14-year-olds were less likely to experience ST-11 cc and ST-269 cc disease, and >= 25-year-olds were more likely to experience disease due to less common ccs and unassigned STs. Younger and older subjects were vulnerable to a more diverse set of genotypes, indicating the more clonal nature of genotypes affecting adolescents and young adults. Knowledge of temporal and spatial diversity and the dynamics of meningococcal populations is essential for disease control by vaccines, as coverage is lineage specific. The nonrandom age distribution of hyperinvasive lineages has consequences for the design and implementation of vaccines, as different variants, or perhaps targets, may be required for different age groups.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

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