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Neurologic Function...
Neurologic Function and Health-Related Quality of Life in Patients Following Targeted Temperature Management at 33 degrees C vs 36 degrees C After Out-of-Hospital Cardiac Arrest A Randomized Clinical Trial
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- Cronberg, Tobias (författare)
- Dept Neurol & Rehabil Med, Skåne Univ Hosp, Lund, Sweden; Dept Clin Sci, Lund Univ, Lund, Sweden
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- Lilja, Gisela (författare)
- Dept Neurol & Rehabil Med, Skåne Univ Hosp, Lund, Sweden; Dept Clin Sci, Lund Univ, Lund, Sweden
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- Horn, Janneke (författare)
- Acad Med Ctr, Dept Intens Care, Univ Amsterdam, Amsterdam, Netherlands
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- Kjaergaard, Jesper (författare)
- Ctr Heart, Dept Cardiol, Copenhagen Univ Hosp (Rigshosp), Copenhagen, Denmark
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- Wise, Matt P. (författare)
- Adult Crit Care, Univ Wales Hosp, Cardiff, England
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- Pellis, Tommaso (författare)
- Intens Care Unit, Santa Maria Angeli, Pordenone, Italy
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- Hovdenes, Jan (författare)
- Dept Anesthesiol, Oslo Univ Hosp (Rikshosp), Univ Oslo, Oslo, Norway
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- Gasche, Yvan (författare)
- Dept Anesthesiol Pharmacol & Intens Care, Univ Hosp Geneva, Geneva, Switzerland
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- Aneman, Anders (författare)
- Dept Intens Care, Liverpool Hosp, Sydney NSW, Australia
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- Stammet, Pascal (författare)
- Dept Anesthesiol & Intens Care, Ctr Hosp, Luxembourg, Luxembourg
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- Erlinge, David (författare)
- Dept Clin Sci, Lund Univ, Lund, Sweden; Dept Cardiol, Lund Univ, Lund, Sweden
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- Friberg, Hans (författare)
- Dept Clin Sci, Lund, Lund Univ, Sweden; Dept Intens & Perioperat Care, Skåne Univ Hosp, Lund, Sweden
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- Hassager, Christian (författare)
- Ctr Heart, Dept Cardiol, Copenhagen Univ Hosp (Rigshosp), Copenhagen, Denmark
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- Kuiper, Michael (författare)
- Acad Med Ctr, Dept Intens Care, Univ Amsterdam, Amsterdam, Netherlands; Dept Intens Care, Med Ctr Leeuwarden, Leeuwarden, Netherlands
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- Wanscher, Michael (författare)
- Ctr Heart, Dept Cardiothorac Anesthesiol, Copenhagen Univ Hosp (Rigshosp), Copenhagen, Denmark
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- Bosch, Frank (författare)
- Dept Intens Care, Rijnstaate Hosp, Arnhem, Netherlands
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- Cranshaw, Julius (författare)
- Dept Intens Care, Royal Bournemouth Hosp, Bournemouth, England
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- Kleger, Gian-Reto (författare)
- Dept Intens Care, Kantonsspital, St Gallen, Switzerland
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- Persson, Stefan (författare)
- Dept Anesthesia & Intens Care, Örebro University Hospital, Örebro, Sweden
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- Unden, Johan (författare)
- Dept Intens & Perioperat Care, Skåne Univ Hosp, Malmö, Sweden
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- Walden, Andrew (författare)
- Dept Intens Care, Royal Berkshire Hosp, Reading, England
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- Winkel, Per (författare)
- Ctr Clin Intervent Res, Copenhagen Trial Unit, Copenhagen Univ Hosp R(igshosp), Copenhagen, Denmark
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- Wetterslev, Jorn (författare)
- Ctr Clin Intervent Res, Copenhagen Trial Unit, Copenhagen Univ Hosp (Rigshosp), Copenhagen, Denmark
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- Nielsen, Niklas (författare)
- Dept Clin Sci, Lund Univ, Lund, Sweden; Anesthesia & Intens Care, Helsingborg Hosp, Helsingborg, Sweden
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(creator_code:org_t)
- American Medical Association, 2015
- 2015
- Engelska.
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Ingår i: JAMA Neurology. - : American Medical Association. - 2168-6149 .- 2168-6157. ; 72:6, s. 634-641
- Relaterad länk:
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https://jamanetwork....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- IMPORTANCE Brain injury affects neurologic function and quality of life in survivors after cardiac arrest. OBJECTIVE To compare the effects of 2 target temperature regimens on long-term cognitive function and quality of life after cardiac arrest. DESIGN, SETTING, AND PARTICIPANTS In this multicenter, international, parallel group, assessor-masked randomized clinical trial performed from November 11, 2010, through January 10, 2013, we enrolled 950 unconscious adults with cardiac arrest of presumed cardiac cause from 36 intensive care units in Europe and Australia. Eleven patients were excluded from analysis for a total sample size of 939. INTERVENTIONS Targeted temperature management at 33 degrees C vs 36 degrees C. MAIN OUTCOMES AND MEASURES Cognitive function was measured by the Mini-Mental State Examination (MMSE) and assessed by observers through the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Patients reported their activities in daily life and mental recovery through Two Simple Questions and their quality of life through the Medical Outcomes Study 36-Item Short Form Health Survey, version 2. RESULTS In the modified intent-to-treat population, including nonsurvivors, the median MMSE score was 14 in the 33 degrees C group (interquartile range [IQR], 0-28) vs 17 in the 36 degrees C group (IQR, 0-29) (P = .77), and the IQCODE score was 115 (IQR, 79-130) vs 115 (IQR, 80-130) (P = .57) in the 33 degrees C and 36 degrees C groups, respectively. The median MMSE score for survivors was within the reference range and similar (33 degrees C group median, 28; IQR, 26-30; vs 36 degrees C group median, 28; IQR, 25-30; P = .61). The median IQCODE score was within the minor deficit range (33 degrees C group median, 79.5; IQR, 78.0-85.9; vs 36 degrees C group median, 80.7; IQR, 78.0-86.9; P = .04). A total of 18.8% vs 17.5% of survivors reported needing help with everyday activities (P = .71), and 66.5% in the 33 degrees C group vs 61.8% in the 36 degrees C group reported that they thought they had made a complete mental recovery (P = .32). The mean (SD) mental component summary score was 49.1 (12.5) vs 49.0 (12.2) (P = .79), and the mean (SD) physical component summary score was 46.8 (13.8) and 47.5 (13.8) (P = .45), comparable to the population norm. CONCLUSIONS AND RELEVANCE Quality of life was good and similar in patients with cardiac arrest receiving targeted temperature management at 33 degrees C or 36 degrees C. Cognitive function was similar in both intervention groups, but many patients and observers reported impairment not detected previously by standard outcome scales.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- Av författaren/redakt...
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Cronberg, Tobias
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Lilja, Gisela
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Horn, Janneke
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Kjaergaard, Jesp ...
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Wise, Matt P.
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Pellis, Tommaso
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visa fler...
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Hovdenes, Jan
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Gasche, Yvan
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Aneman, Anders
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Stammet, Pascal
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Erlinge, David
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Friberg, Hans
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Hassager, Christ ...
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Kuiper, Michael
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Wanscher, Michae ...
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Bosch, Frank
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Cranshaw, Julius
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Kleger, Gian-Ret ...
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Persson, Stefan
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Unden, Johan
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Walden, Andrew
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Winkel, Per
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Wetterslev, Jorn
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Nielsen, Niklas
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JAMA Neurology
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Örebro universitet