Autoimmune Disease in First-Degree Relatives and Spouses of Individuals With Celiac Disease

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Emilsson, LouisePrimary Care Res Unit Vårdctr Värmlands Nysäter, Värmland County, Karlstad, Sweden; Inst Hlth & Soc, Dept Hlth Management & Hlth Econ, Univ Oslo, Oslo, Norway (author)

Autoimmune Disease in First-Degree Relatives and Spouses of Individuals With Celiac Disease

Article/chapterEnglish2015

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Elsevier BV,2015
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LIBRIS-ID:oai:DiVA.org:oru-56348
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56348URI
https://doi.org/10.1016/j.cgh.2015.01.026DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:131875279URI

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Language:English
Summary in:English

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BACKGROUND & AIMS: First-degree relatives of individuals with celiac disease are at increased risk for this disorder, but little is known about their risk for other autoimmune diseases. We assessed the risk of nonceliac autoimmune disease in first-degree relatives and spouses of people with celiac disease. METHODS: We identified individuals with celiac disease by searching computerized duodenal and jejunal biopsies, collected from 1969 through 2008, at 28 pathology departments in Sweden. Celiac disease was identified based on biopsy reports of villous atrophy (equal to Marsh grade 3; n = 29,096). Individuals with celiac disease were matched with up to 5 controls (people without celiac disease) for sex, age, county, and calendar year (total, 144,522 controls). Through Swedish health care registries, we identified all first-degree relatives (fathers, mothers, siblings, and offspring) and spouses of individuals with celiac disease (n = 84,648) and controls (n = 430,942). We used Cox regression analysis to calculate hazard ratios (HRs) for nonceliac autoimmune disease (Crohn's disease, type 1 diabetes mellitus, hypothyroidism, hyperthyroidism, psoriasis, rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, or ulcerative colitis) in these groups. RESULTS: During the follow-up period (median, 10.8 y), 3333 of the first-degree relatives of patients with celiac disease (3.9%) and 12,860 relatives of controls (3.0%) had an autoimmune disease other than celiac disease. First-degree relatives of people with celiac disease were at increased risk of nonceliac autoimmune disease, compared with controls (HR, 1.28; 95% confidence interval, 1.23-1.33), as were spouses (HR, 1.20; 95% confidence interval, 1.06-1.35). Risk estimates for nonceliac autoimmune disease did not differ between first-degree relatives and spouses of individuals with celiac disease (interaction test: P =.11). HRs for nonceliac autoimmune disease were highest in the first 2 years of follow-up evaluation. CONCLUSIONS: First-degree relatives and spouses of individuals with celiac disease are at increased risk of nonceliac autoimmune disease. In addition to genetic factors, environmental factors and ascertainment bias might contribute to the increased risk of autoimmunity in first-degree relatives of individuals with celiac disease.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Population Study
Risk Factor
Genetics
Heredity
Celiac
Cohort
Shared Genetics
Autoimmune

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Wijmenga, CiscaDept Genet, Univ Med Ctr Groningen, Univ Groningen, Groningen, Netherlands (author)
Murray, Joseph A.Dept Internal Med, Div Gastroenterol & Hepatol, Mayo Clin, Rochester MN, USA (author)
Ludvigsson, Jonas F.Karolinska Institutet,Region Örebro län,Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden; Dept Pediat, Örebro University Hospital, Örebro, Sweden(Swepub:oru)jsln (author)
Primary Care Res Unit Vårdctr Värmlands Nysäter, Värmland County, Karlstad, Sweden; Inst Hlth & Soc, Dept Hlth Management & Hlth Econ, Univ Oslo, Oslo, NorwayDept Genet, Univ Med Ctr Groningen, Univ Groningen, Groningen, Netherlands (creator_code:org_t)

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In:Clinical Gastroenterology and Hepatology: Elsevier BV13:7, s. 1271-1277.e21542-35651542-7714

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By the author/editor: Emilsson, Louise; Wijmenga, Cisca; Murray, Joseph A ...; Ludvigsson, Jona ...

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