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  • Davies, Kerrie A.EUCLID European Coordinators, Univ Leeds, Leeds, England (författare)

Underdiagnosis of Clostridium difficile across Europe : the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID)

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • Elsevier,2014
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-56368
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56368URI
  • https://doi.org/10.1016/S1473-3099(14)70991-0DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agency:Astellas Pharmaceuticals Europe 
  • Background: Variations in testing for Clostridium difficile infection can hinder patients' care, increase the risk of transmission, and skew epidemiological data. We aimed to measure the underdiagnosis of C difficile infection across Europe.Methods: We did a questionnaire-based study at 482 participating hospitals across 20 European countries. Hospitals were questioned about their methods and testing policy for C difficile infection during the periods September, 2011, to August, 2012, and September, 2012, to August, 2013. On one day in winter, 2012-13 (December, 2012, or January, 2013), and summer, 2013 (July or August), every hospital sent all diarrhoeal samples submitted to their microbiology laboratory to a national coordinating laboratory for standardised testing of C difficile infection. Our primary outcome measures were the rates of testing for and cases of C difficile infection per 10 000 patient bed-days. Results of local and national C difficile infection testing were compared with each other. If the result was positive at the national laboratory but negative at the local hospital, the result was classified as undiagnosed C difficile infection. We compared differences in proportions with the Mann-Whitney test, or McNemar's test if data were matched.Findings: During the study period, participating hospitals reported a mean of 65.8 tests (country range 4. 6-223.3) for C difficile infection per 10 000 patient-bed days and a mean of 7.0 cases (country range 0.7-28.7) of C difficile infection per 10 000 patient-bed days. Only two-fifths of hospitals reported using optimum methods for testing of C difficile infection (defined by European guidelines), although the number of participating hospitals using optimum methods increased during the study period, from 152 (32%) of 468 in 2011-12 to 205 (48%) of 428 in 2012-13. Across all 482 European hospitals on the two sampling days, 148 (23%) of 641 samples positive for C difficile infection (as determined by the national laboratory) were not diagnosed by participating hospitals because of an absence of clinical suspicion, equating to about 74 missed diagnoses per day.Interpretation: A wide variety of testing strategies for C difficile infection are used across Europe. Absence of clinical suspicion and suboptimum laboratory diagnostic methods mean that an estimated 40 000 inpatients with C difficile infection are potentially undiagnosed every year in 482 European hospitals.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Longshaw, Christopher M.Astellas Pharma Europe, Chertsey, England (författare)
  • Davis, Georgina L.EUCLID European Coordinators, Univ Leeds, Leeds, England (författare)
  • Bouza, EmilioMicrobiol Clin E Infecc, Catedral Jefe Serv, Gen Hosp, Univ Gregorio Maranon, Madrid, Spain (författare)
  • Barbut, FredericNatl Reference Lab Clostridium Difficile, Univ Paris 06, Paris, France (författare)
  • Barna, ZsuzsannaDept Bacteriol, Natl Ctr Epidemiol, Budapest, Hungary (författare)
  • Delmee, MichelInstitute of Experimental and Clinical Research, Catholic Univ Louvain, Brussels, Belgium (författare)
  • Fitzpatrick, FidelmaHlth Protect Surveillance Ctr, Dublin, Ireland; Beaumont Hosp, Dublin, Ireland (författare)
  • Ivanova, KateNatl Ctr Infect & Parasit Dis, Sofia, Bulgaria (författare)
  • Kuijper, EdMed Ctr, Dept Med Microbiol, Leiden Univ, Leiden, Netherlands (författare)
  • Macovei, Ioana S.Cantacuzino Natl Inst Res & Dev Microbiol & Immun, Bucharest, Romania (författare)
  • Mentula, SiljaBacteriol Unit, Natl Inst Hlth & Welf (THL), Helsinki, Finland (författare)
  • Mastrantonio, PaolaDept Infect Dis, Ist Super Sanita, Rome, Italy (författare)
  • von Mueller, LutzMed Ctr, Inst Med Microbiol & Hyg, Univ Saarland, Homburg, Germany (författare)
  • Oleastro, MonicaDept Infect Dis, Natl Inst Hlth Dr Ricardo Jorge, Lisbon, Portugal (författare)
  • Petinaki, EfthymiaSch Med, Univ Hosp, Univ Thessalia, Larisa, Greece (författare)
  • Pituch, HannaDept Med Microbiol, Med Univ Warsaw, Warsaw, Poland (författare)
  • Norén, Torbjörn,1955-Region Örebro län(Swepub:oru)trnn (författare)
  • Novakova, ElenaJessenius Fac Med Martin, Comenius Univ, Martin, Slovakia (författare)
  • Nyc, OtakarDept Med Microbiol, Univ Hosp Motol, Prague, Czech Republic (författare)
  • Rupnik, MajaFac Med, Univ Maribor, Maribor, Slovenia; Natl Lab Hlth Environm & Food (NLZOH), Maribor, Slovenia (författare)
  • Schmid, DanielaInst Med Microbiol & Hyg, Austrian Agcy Hlth & Food Safety, Vienna,Austria. (författare)
  • Wilcox, Mark H.EUCLID European Coordinators, Univ Leeds, Leeds, England (författare)
  • EUCLID European Coordinators, Univ Leeds, Leeds, EnglandAstellas Pharma Europe, Chertsey, England (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The Lancet - Infectious diseases: Elsevier14:12, s. 1208-12191473-30991474-4457

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