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Underdiagnosis of C...
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Davies, Kerrie A.EUCLID European Coordinators, Univ Leeds, Leeds, England
(författare)
Underdiagnosis of Clostridium difficile across Europe : the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID)
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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Elsevier,2014
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-56368
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56368URI
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https://doi.org/10.1016/S1473-3099(14)70991-0DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agency:Astellas Pharmaceuticals Europe
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Background: Variations in testing for Clostridium difficile infection can hinder patients' care, increase the risk of transmission, and skew epidemiological data. We aimed to measure the underdiagnosis of C difficile infection across Europe.Methods: We did a questionnaire-based study at 482 participating hospitals across 20 European countries. Hospitals were questioned about their methods and testing policy for C difficile infection during the periods September, 2011, to August, 2012, and September, 2012, to August, 2013. On one day in winter, 2012-13 (December, 2012, or January, 2013), and summer, 2013 (July or August), every hospital sent all diarrhoeal samples submitted to their microbiology laboratory to a national coordinating laboratory for standardised testing of C difficile infection. Our primary outcome measures were the rates of testing for and cases of C difficile infection per 10 000 patient bed-days. Results of local and national C difficile infection testing were compared with each other. If the result was positive at the national laboratory but negative at the local hospital, the result was classified as undiagnosed C difficile infection. We compared differences in proportions with the Mann-Whitney test, or McNemar's test if data were matched.Findings: During the study period, participating hospitals reported a mean of 65.8 tests (country range 4. 6-223.3) for C difficile infection per 10 000 patient-bed days and a mean of 7.0 cases (country range 0.7-28.7) of C difficile infection per 10 000 patient-bed days. Only two-fifths of hospitals reported using optimum methods for testing of C difficile infection (defined by European guidelines), although the number of participating hospitals using optimum methods increased during the study period, from 152 (32%) of 468 in 2011-12 to 205 (48%) of 428 in 2012-13. Across all 482 European hospitals on the two sampling days, 148 (23%) of 641 samples positive for C difficile infection (as determined by the national laboratory) were not diagnosed by participating hospitals because of an absence of clinical suspicion, equating to about 74 missed diagnoses per day.Interpretation: A wide variety of testing strategies for C difficile infection are used across Europe. Absence of clinical suspicion and suboptimum laboratory diagnostic methods mean that an estimated 40 000 inpatients with C difficile infection are potentially undiagnosed every year in 482 European hospitals.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Longshaw, Christopher M.Astellas Pharma Europe, Chertsey, England
(författare)
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Davis, Georgina L.EUCLID European Coordinators, Univ Leeds, Leeds, England
(författare)
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Bouza, EmilioMicrobiol Clin E Infecc, Catedral Jefe Serv, Gen Hosp, Univ Gregorio Maranon, Madrid, Spain
(författare)
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Barbut, FredericNatl Reference Lab Clostridium Difficile, Univ Paris 06, Paris, France
(författare)
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Barna, ZsuzsannaDept Bacteriol, Natl Ctr Epidemiol, Budapest, Hungary
(författare)
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Delmee, MichelInstitute of Experimental and Clinical Research, Catholic Univ Louvain, Brussels, Belgium
(författare)
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Fitzpatrick, FidelmaHlth Protect Surveillance Ctr, Dublin, Ireland; Beaumont Hosp, Dublin, Ireland
(författare)
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Ivanova, KateNatl Ctr Infect & Parasit Dis, Sofia, Bulgaria
(författare)
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Kuijper, EdMed Ctr, Dept Med Microbiol, Leiden Univ, Leiden, Netherlands
(författare)
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Macovei, Ioana S.Cantacuzino Natl Inst Res & Dev Microbiol & Immun, Bucharest, Romania
(författare)
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Mentula, SiljaBacteriol Unit, Natl Inst Hlth & Welf (THL), Helsinki, Finland
(författare)
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Mastrantonio, PaolaDept Infect Dis, Ist Super Sanita, Rome, Italy
(författare)
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von Mueller, LutzMed Ctr, Inst Med Microbiol & Hyg, Univ Saarland, Homburg, Germany
(författare)
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Oleastro, MonicaDept Infect Dis, Natl Inst Hlth Dr Ricardo Jorge, Lisbon, Portugal
(författare)
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Petinaki, EfthymiaSch Med, Univ Hosp, Univ Thessalia, Larisa, Greece
(författare)
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Pituch, HannaDept Med Microbiol, Med Univ Warsaw, Warsaw, Poland
(författare)
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Norén, Torbjörn,1955-Region Örebro län(Swepub:oru)trnn
(författare)
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Novakova, ElenaJessenius Fac Med Martin, Comenius Univ, Martin, Slovakia
(författare)
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Nyc, OtakarDept Med Microbiol, Univ Hosp Motol, Prague, Czech Republic
(författare)
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Rupnik, MajaFac Med, Univ Maribor, Maribor, Slovenia; Natl Lab Hlth Environm & Food (NLZOH), Maribor, Slovenia
(författare)
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Schmid, DanielaInst Med Microbiol & Hyg, Austrian Agcy Hlth & Food Safety, Vienna,Austria.
(författare)
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Wilcox, Mark H.EUCLID European Coordinators, Univ Leeds, Leeds, England
(författare)
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EUCLID European Coordinators, Univ Leeds, Leeds, EnglandAstellas Pharma Europe, Chertsey, England
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The Lancet - Infectious diseases: Elsevier14:12, s. 1208-12191473-30991474-4457
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Till lärosätets databas
- Av författaren/redakt...
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Davies, Kerrie A ...
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Longshaw, Christ ...
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Davis, Georgina ...
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Bouza, Emilio
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Barbut, Frederic
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Barna, Zsuzsanna
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visa fler...
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Delmee, Michel
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Fitzpatrick, Fid ...
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Ivanova, Kate
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Kuijper, Ed
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Macovei, Ioana S ...
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Mentula, Silja
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Mastrantonio, Pa ...
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von Mueller, Lut ...
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Oleastro, Monica
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Petinaki, Efthym ...
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Pituch, Hanna
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Norén, Torbjörn, ...
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Novakova, Elena
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Nyc, Otakar
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Rupnik, Maja
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Schmid, Daniela
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Wilcox, Mark H.
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