L773:0148 5717
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Prevalence and Molecular Epidemiological Typing of Penicillinase-Producing Neisseria gonorrhoeae and Their bla(TEM-135) Gene Variants in Nanjing, China
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- Chen, Shao-Chun (författare)
- China CDC, National Center STD Control, Nanjing, Peoples R China; Chinese Academy of Medical Science, Inst Dermatol, Nanjing, Peoples R China; Peking Union Med Coll, Nanjing, Peoples R China; Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing, Peoples R China
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- Yin, Yue-Ping (författare)
- China CDC, Natl Ctr STD Control, Nanjing, Peoples R China; Chinese Acad Med Sci, Inst Dermatol, Nanjing, Peoples R China;Peking Union Med Coll, Nanjing, Peoples R China; Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing, Peoples R China
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- Dai, Xiu-Qin (författare)
- China CDC, Natl Ctr STD Control, Nanjing, Peoples R China;Chinese Acad Med Sci, Inst Dermatol, Nanjing, Peoples R China;Peking Union Med Coll, Nanjing, Peoples R China;Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing, Peoples R China
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- (creator_code:org_t)
- 2013
- 2013
- Engelska.
- Ingår i: Sexually Transmitted Diseases. - 0148-5717 .- 1537-4521. ; 40:11, s. 872-876
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background: This study aimed to investigate the prevalence of penicillinase-producing Neisseria gonorrhoeae (PPNG) and their bla(TEM-135) gene variant in 2007 and 2012 in Nanjing, China. In addition, molecular epidemiological typing of all isolates was performed to elucidate the genetic relationships of the PPNG strains. Methods: A total of 199 and 77 N. gonorrhoeae isolates were collected at the National Center for STD Control in 2007 and 2012, respectively. Nitrocefin tests were performed to identify PPNG. Mismatch amplification mutation assay was used to identify bla(TEM-135). All isolates were genotyped using N. gonorrhoeae multiantigen sequence typing (NG-MAST), and additionally, porB-based phylogenetic analysis was performed for the PPNG isolates. Results: The total prevalence of PPNG isolates was 41% (114/276) and 58% (66/114) of these PPNG isolates possessed bla(TEM-135). In 2007, 45% (90/199) produced beta-lactamase, and of those PPNG, 58% (52/90) possessed bla(TEM-135). In 2012, 31% (24/77) were PPNG, and 58% (14/24) of those isolates contained bla(TEM-135). There were 162 NG-MAST STs among the 276 isolates, and 89 of those were novel STs. A strong association between specific NG-MAST STs and bla(TEM-135) was found, and the porB-based phylogenetic analysis showed a distant evolutionary relationship between isolates in 2007 and isolates in 2012. Conclusions: A high prevalence of PPNG and bla(TEM-135) was found in Nanjing, China. bla(TEM-135) might be a precursor in the evolution into an extended-spectrum beta-lactamase that can degrade ceftriaxone, which stresses the need to continuously monitor PPNG, bla(TEM-135), and additional evolving bla(TEM) gene variants.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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