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Risk of Dementia in...
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Lebwohl, BenjaminDept Med, Celiac Dis Ctr, Columbia Univ Coll Phys & Surg, New York NY, USA; Dept Med Epidemiol & Biostat, Karolinska Univ Hosp, Stockholm, Sweden; Karolinska Institute, Stockholm, Sweden; Dept Med, Columbia Univ Coll Phys & Surg, New York, NY, USA; Med Ctr, Mailman Sch Publ Hlth, Dept Epidemiol, Columbia Univ, New York NY, USA
(författare)
Risk of Dementia in Patients with Celiac Disease : A Population-Based Cohort Study
- Artikel/kapitelEngelska2016
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-56520
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56520URI
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https://doi.org/10.3233/JAD-150388DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132388123URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Patients with celiac disease (CD) frequently report cognitive symptoms when they are exposed to gluten, and cognitive deficits have been quantified in patients with newly diagnosed CD. Objective: To determine whether patients with CD have an increased risk of dementia. Methods: Using a population-based database of older adults (age >= 50 years) with histologically proven CD (duodenal/jejunal villous atrophy) from all 28 pathology departments in Sweden, we compared the incidence of a subsequent dementia diagnosis to those of age-and gender-matched controls. Results: Among patients with CD (n = 8,846) and controls (n = 43,474), the median age was 63 years and 56% were female. During a median follow-up time of 8.4 years, dementia was diagnosed in 4.3% of CD patients and 4.4% of controls (HR 1.07; 95% CI 0.95-1.20). Although there was an increased risk of dementia in the first year following a diagnosis of CD (HR 1.73; 95% CI 1.15-2.61), this risk was not present in the whole observation period. Among those subjects with a dementia subtype specified, the increased risk was restricted to vascular dementia (HR 1.28; 95% CI 1.00-1.64) and was not present for Alzheimer's dementia (HR 1.12; 95% CI 0.91-1.37). Conclusions: Patients with CD are not at increased risk for dementia overall, though subgroup analysis suggests that they may be at increased risk for vascular dementia.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Luchsinger, Jose A.Dept Med, Columbia Univ Coll Phys & Surg, New York NY, USA; Med Ctr, Mailman Sch Publ Hlth, Dept Epidemiol, Columbia Univ, New York NY, USA
(författare)
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Freedberg, Daniel E.Dept Med, Columbia Univ Coll Phys & Surg, New York NY, USA
(författare)
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Green, Peter H. R.Dept Med, Celiac Dis Ctr, Columbia Univ Coll Phys & Surg, New York NY, USA
(författare)
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Ludvigsson, Jonas F.Karolinska Institutet,Region Örebro län,Dept Med Epidemiol & Biostat, Karolinska Univ Hosp, Stockholm, Sweden; Karolinska Inst, Stockholm, Sweden; Dept Pediat, Örebro University Hospital, Örebro, Sweden(Swepub:oru)jsln
(författare)
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Dept Med, Celiac Dis Ctr, Columbia Univ Coll Phys & Surg, New York NY, USA; Dept Med Epidemiol & Biostat, Karolinska Univ Hosp, Stockholm, Sweden; Karolinska Institute, Stockholm, Sweden; Dept Med, Columbia Univ Coll Phys & Surg, New York, NY, USA; Med Ctr, Mailman Sch Publ Hlth, Dept Epidemiol, Columbia Univ, New York NY, USADept Med, Columbia Univ Coll Phys & Surg, New York NY, USA; Med Ctr, Mailman Sch Publ Hlth, Dept Epidemiol, Columbia Univ, New York NY, USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Alzheimer's Disease49:1, s. 179-1851387-28771875-8908
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