Screening for celiac disease in the general population and in high-risk groups

Ludvigsson, Jonas F.Karolinska Institutet,Region Örebro län,Dept Paediat, Örebro University Hospital, Örebro, Sweden; Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden (författare)

Background: Celiac disease (CD) occurs in approximately 1% of the Western population. It is a lifelong disorder that is associated with impaired quality of life (QOL) and an excessive risk of comorbidity and death. Objectives: To review the literature on screening for CD in relation to the current World Health Organization (WHO) criteria for mass screening. Methods: We performed a PubMed search to identify indexed papers on CD screening with a publication date from 1900 until 1 June 2014. When we deemed an abstract relevant, we read the corresponding paper in detail. Results: CD fulfills several WHO criteria for mass screening (high prevalence, available treatment and difficult clinical detection), but it has not yet been established that treatment of asymptomatic CD may reduce the excessive risk of severe complications, leading to higher QOL nor that it is cost-effective. Conclusions: Current evidence is not sufficient to support mass screening for CD, but active case-finding may be appropriate, as we recognize that most patients with CD will still be missed by this strategy. Although proof of benefit is still lacking, screening for CD may be appropriate in high-risk groups.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Celiac disease
gluten
gluten-free diet
review
screening
prevention
risk
quality of life
World Health Organization

Card, Timothy R.Dept Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England (författare)
Kaukinen, KatriSch Med, Univ Tampere, Tampere, Finland; Dept Internal Med, Tampere Univ Hosp, Tampere, Finland;Dept Internal Med, Seinajoki Cent Hosp, Seinajoki, Finland (författare)
Bai, JulioDept Med, C Bonorino Udaondo Gastroenterol Hosp,Univ Salvador, Buenos Aires DF, Argentina (författare)
Zingone, FabianaDept Med & Surg, Univ Salerno, Salerno, Italy (författare)
Sanders, David S.Reg GI & Liver Unit, Royal Hallamshire Hosp, Sheffield, England (författare)
Murray, Joseph A.Coll Med, Dept Immunol, Dept Med, Mayo Clin, Rochester MN, USA (författare)
Region Örebro länDept Paediat, Örebro University Hospital, Örebro, Sweden; Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden (creator_code:org_t)

Ingår i:United European Gastroenterology journal: Wiley3:2, s. 106-1202050-64062050-6414

Av författaren/redakt...: Ludvigsson, Jona ...; Card, Timothy R.; Kaukinen, Katri; Bai, Julio; Zingone, Fabiana; Sanders, David S ...; visa fler...; Murray, Joseph A ...; visa färre...

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