Vitamin D Status 10 Years After Primary Gastric Bypass: Gravely High Prevalence of Hypovitaminosis D and Raised PTH Levels

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Karefylakis, Christos,1982-Dept Endocrinol, Div Internal Med, Örebro Univ Hosp, Örebro, Sweden (författare)

Vitamin D Status 10 Years After Primary Gastric Bypass : Gravely High Prevalence of Hypovitaminosis D and Raised PTH Levels

Artikel/kapitelEngelska2014

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2013-10-28
Springer Science and Business Media LLC,2014
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:oru-56581
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56581URI
https://doi.org/10.1007/s11695-013-1104-yDOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216393URI

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Språk:engelska
Sammanfattning på:engelska

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The primary aim of this study was to evaluate the prevalence of vitamin D deficiency and secondary hyperparathyroidism after Roux-en-Y gastric bypass. Secondly, we have tried to assess predictors for vitamin D deficiency. Five hundred thirty-seven patients who underwent primary Roux-en-Y gastric bypass surgery between 1993 and 2003 at the A-rebro University Hospital and Uppsala University Hospital were eligible for the study. Patients were asked to provide a blood sample between November 2009 and June 2010 and to complete a questionnaire about their postoperative health status. Serum values of 25-OH vitamin D, parathyroid hormone (PTH), alkaline phosphatase (ALP) and calcium were determined. Follow-up was completed in 293 patients, of which 83 % were female, with an age of 49 +/- 9.9 years after a median time of 11 +/- 2.8 years. Vitamin D, PTH and albumin-corrected calcium values were 42 +/- 20.4 nmol/L, 89.1 +/- 52.7 ng/L and 2.3 +/- 0.1 mmol/L, respectively. Of all patients, 65 % were vitamin D deficient, i.e. 25-OH vitamin D < 50 nmol/L, and 69 % had PTH above the upper normal reference range, i.e. > 73 ng/L. Vitamin D was inversely correlated with PTH levels (p < 0.001) and positively correlated with calcium (p = 0.016). Vitamin D did not correlate with ALP. The only factor found to predict vitamin D deficiency was high preoperative body mass index (BMI) (p = 0.008), whereas gender, age, time after surgery and BMI at follow-up did not. Vitamin D deficiency and secondary hyperparathyroidism after Roux-en-Y gastric bypass (RYGB) were confirmed in our study because 65 % of patients had vitamin D deficiency, and 69 % had increased PTH levels more than 10 years after surgery. These data are alarming and highlight the need for improved long-term follow-up. Vitamin D deficiency does not seem to progress with time after surgery, possibly due to weight loss. Only preoperative BMI, cutoff point 43 kg/m(2), was a predictor of vitamin D deficiency at follow-up. Improved long-term follow-up of patients that undergo RYGB is needed.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Vitamin D
Gastric bypass
Hyperparathyroidism
Long-term follow-up

Biuppslag (personer, institutioner, konferenser, titlar ...)

Näslund, IngmarRegion Örebro län,Div Surg, Örebro University Hospital, Örebro, Sweden(Swepub:oru)OUH-in1na (författare)
Edholm, DavidUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)daved963 (författare)
Sundbom, MagnusUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)magsundb (författare)
Karlsson, F AndersUppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)anderska (författare)
Rask, Eva,1958-Ctr Hlth Care Sci, Örebro University Hospital, Örebro, Sweden(Swepub:oru)erk (författare)
Region Örebro länDept Endocrinol, Div Internal Med, Örebro Univ Hosp, Örebro, Sweden (creator_code:org_t)

Sammanhörande titlar

Ingår i:Obesity Surgery: Springer Science and Business Media LLC24:3, s. 343-3480960-89231708-0428

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Av författaren/redakt...: Karefylakis, Chr ...; Näslund, Ingmar; Edholm, David; Sundbom, Magnus; Karlsson, F Ande ...; Rask, Eva, 1958-

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

Artiklar i publikationen: Obesity Surgery

Av lärosätet: Örebro universitet; Uppsala universitet

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