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Decreased Risk of C...
Decreased Risk of Celiac Disease in Patients With Helicobacter pylori Colonization
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- Lebwohl, Benjamin (författare)
- Coll Phys & Surg, Dept Med, Celiac Dis Ctr, Columbia Univ, New York NY, USA; Dept Epidemiol, Mailman Sch Publ Hlth, Columbia Univ, New York NY, USA
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- Blaser, Martin J. (författare)
- Dept Med, Langone Med Ctr, New York University, New York NY, USA
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- Ludvigsson, Jonas F. (författare)
- Karolinska Institutet,Region Örebro län,Dept Med, Clin Epidemiol Unit, Karolinska University Hospital, Stockholm, Sweden; Karolinska Instute, Stockholm, Sweden; Dept Pediat, Örebro University Hospital, Örebro, Sweden
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- Green, Peter H. R. (författare)
- Coll Phys & Surg, Dept Med, Celiac Dis Ctr, Columbia Univ, New York NY, USA
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- Rundle, Andrew (författare)
- Dept Epidemiol, Mailman Sch Publ Hlth, Columbia Univ, New York NY, USA
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- Sonnenberg, Amnon (författare)
- Dept Med, Oregon Hlth & Sci Univ, Portland OR, USA
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- Genta, Robert M. (författare)
- Dept Pathol, Univ Texas SW Med Ctr, Dallas TX, USA; Miraca Life Sci Res Inst, Irving TX, USA
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(creator_code:org_t)
- 2013-10-11
- 2013
- Engelska.
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Ingår i: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 178:12, s. 1721-1730
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The prevalence of celiac disease (CD) has increased in recent decades without a clear explanation. The hygiene hypothesis theorizes that decreased exposure to bacterial antigens may trigger autoimmunity. We aimed to determine whether Helicobacter pylori infection and CD were associated among patients undergoing upper gastrointestinal endoscopy. We performed a cross-sectional study of patients who underwent esophagogastroduodenoscopy with submission of gastric and duodenal biopsies to Miraca Life Sciences, Inc. (Irving, Texas), a US commercial pathology laboratory, during a 4.5-year period (January 2008June 2012). We compared the prevalence of H. pylori in CD patients with that in persons without CD. We performed multiple logistic regression analysis, adjusting odds ratios for patient age, gender, and racial, ethnic, and socioeconomic factors. Among 136,179 patients, a total of 2,689 (2.0) had CD. H. pylori prevalence was significantly lower in patients with CD (4.4) than in those without CD (8.8; P 0.0001). After adjustment for the above covariates, this inverse relationship remained strong (adjusted odds ratio (OR) 0.48, 95 confidence interval (CI): 0.40, 0.58). The relationships were similar in men (unadjusted OR 0.51, 95 CI: 0.38, 0.69) and women (unadjusted OR 0.46, 95 CI: 0.36, 0.58) and in all age groups. We conclude that H. pylori presence and CD are inversely associated, a relationship that persists after adjustment for socioeconomic factors. Future studies should address whether H. pylori modulates immune responses to ingested gluten.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- celiac disease
- gluten
- Helicobacter pylori
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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