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  • Sackey, H.Karolinska Institutet (author)

Arm lymphoedema after axillary surgery in women with invasive breast cancer

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-02-17
  • Wiley-Blackwell,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-56711
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56711URI
  • https://doi.org/10.1002/bjs.9401DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:129026973URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-227912URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: The primary aim was to compare arm lymphoedema after sentinel lymph node biopsy (SLNB) alone versus axillary lymph node dissection (ALND) in women with node-negative and node-positive breast cancer. The secondary aim was to examine the potential association between self-reported and objectively measured arm lymphoedema.Methods: Women who had surgery during 1999-2004 for invasive breast cancer in four centres in Sweden were included. The study groups were defined by the axillary procedure performed and the presence of axillary metastases: SLNB alone, ALND without axillary metastases, and ALND with axillary metastases. Before surgery, and 1, 2 and 3years after operation, arm volume was measured and a questionnaire regarding symptoms of arm lymphoedema was completed. A mixed model was used to determine the adjusted mean difference in arm volume between the study groups, and generalized estimating equations were employed to determine differences in self-reported arm lymphoedema.Results: One hundred and forty women had SLNB alone, 125 had node-negative ALND and 155 node-positive ALND. Women who underwent SLNB had no increase in postoperative arm volume over time, whereas both ALND groups showed a significant increase. The risk of self-reported arm lymphoedema 1, 2 and 3years after surgery was significantly lower in the SLNB group compared with that in both ALND groups. Three years after surgery there was a significant association between increased arm volume and self-reported symptoms of arm lymphoedema.Conclusion: SLNB is associated with a minimal risk of increased arm volume and few symptoms of arm lymphoedema, significantly less than after ALND, regardless of lymph node status.Minimal after sentinel node biopsy

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Magnuson, A.Clinical Epidemiology and Biostatistics (author)
  • Sandelin, K.Karolinska Institutet (author)
  • Liljegren, Göran,1948-Region Örebro län,Department of Surgery, Örebro University Hospital, Örebro, Sweden(Swepub:oru)gnln (author)
  • Bergkvist, LeifUppsala universitet,Centrum för klinisk forskning, Västerås,Institutionen för kirurgiska vetenskaper(Swepub:uu)leber451 (author)
  • Fulep, Z.Department of Surgery, Örebro University Hospital, Örebro, Sweden (author)
  • Celebioglu, F.Karolinska Institutet (author)
  • Frisell, J.Karolinska Institutet (author)
  • Karolinska InstitutetClinical Epidemiology and Biostatistics (creator_code:org_t)

Related titles

  • In:British Journal of Surgery: Wiley-Blackwell101:4, s. 390-3970007-13231365-2168

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