Increased Risk of IgA Nephropathy Among Individuals With Celiac Disease

Welander, AdinaDept Med, Clin Epidemiol Unit, Karolinska Univ Hosp, Stockholm, Sweden (author)

Goal: To determine the risk of future biopsy-verified IgA nephropathy (IgAN) among individuals with biopsy-verified celiac disease (CD). Background: Individuals with CD suffer increased risk of end-stage renal disease. An association between CD and IgAN has been suggested; however, results have been inconclusive and no previous study has considered the risk of IgAN in biopsy-verified CD. Study: We performed a population-based prospective cohort study. We identified 27,160 individuals with CD (Marsh stage III) and no previous renal disease through small-intestinal biopsy reports obtained between July 1969 and February 2008 in all (n=28) Swedish pathology departments. Individuals with IgAN were identified by biopsy reports acquired at the 4 Swedish pathology departments specialized in renal pathology. Cox regression analysis was used to determine the risk of future IgAN among individuals with CD compared with 133,949 age-matched and sex-matched reference individuals. Results: Seven (0.026%) individuals with CD and 11 (0.008%) reference individuals developed IgAN. We found an increased risk of biopsy-verified IgAN among individuals with CD [hazard ratio, 3.03; 95% confidence interval, 1.22-7.56]. The risk increase remained statistically significant after adjustment for prior liver disease and country of birth. Conclusions: Individuals with CD suffer a 3-fold increased risk of future IgAN. Our findings warrant awareness of renal function in individuals with CD.

Sundelin, BirgittaKarolinska Institutet (author)
Fored, MichaelKarolinska Institutet (author)
Ludvigsson, Jonas F.Karolinska Institutet,Region Örebro län,Dept Pediat(Swepub:oru)jsln (author)
Karolinska InstitutetDept Med, Clin Epidemiol Unit, Karolinska Univ Hosp, Stockholm, Sweden (creator_code:org_t)

In:Journal of Clinical Gastroenterology: Lippincott Williams & Wilkins47:8, s. 678-6830192-07901539-2031

By the author/editor: Welander, Adina; Sundelin, Birgit ...; Fored, Michael; Ludvigsson, Jona ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

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