Mortality Rate in Children Born to Mothers and Fathers With Celiac Disease: A Nationwide Cohort Study

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Zugna, DanielaCanc Epidemiol Unit, Centrr Rieferimento Epidemiol & Prevenz Oncol Piemon, Turin, Italy; Univ Turin, Turin, Italy (författare)

Mortality Rate in Children Born to Mothers and Fathers With Celiac Disease : A Nationwide Cohort Study

Artikel/kapitelEngelska2013

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2013-04-25
Oxford University Press,2013
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LIBRIS-ID:oai:DiVA.org:oru-56794
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56794URI
https://doi.org/10.1093/aje/kws397DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:126853056URI

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Språk:engelska
Sammanfattning på:engelska

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Anmärkningar

Celiac disease (CD) is associated with increased mortality rate and adverse pregnancy outcome, but little is known about offspring mortality rate. In this nationwide retrospective cohort study, we identified persons whose biopsy-verified CD was diagnosed in Sweden in 19692008. We compared mortality rates in children born to mothers with and without CD (n 16,121 vs. n 61,782) and children born to fathers with and without CD (n 9,289 vs. n 32,984). Median age of offspring at end of follow-up was 28.7 (range, 16.739.7) years. We also examined mortality rates in children born to mothers with undiagnosed CD (later CD diagnosis; n 12,919) and diagnosed CD (n 3,202) to determine if intrauterine exposures associated with CD could affect offspring mortality rate. We estimated hazard ratios for death by using Cox regression. Death rates were independent of maternal CD (60 deaths per 100,000 person-years in children of mothers with CD, vs. 54 in controls) and paternal CD (53 deaths per 100,000 person-years in children of fathers with CD, vs. 53 in controls). Corresponding adjusted hazard ratios were 1.09 (95 confidence interval: 0.95, 1.26) for maternal CD and 1.02 (95 confidence interval: 0.85, 1.23) for paternal CD. Death rates were similar in children born to mothers with undiagnosed CD and in children whose mothers had diagnosed CD during pregnancy. Parental CD does not seem to influence mortality rate in offspring, which suggests that neither genetic influences of CD nor intrauterine conditions have adverse effects on offspring mortality rate.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
autoimmunity
celiac disease
death
inflammation
mortality
pregnancy

Biuppslag (personer, institutioner, konferenser, titlar ...)

Richiardi, LorenzoCanc Epidemiol Unit, Centrr Rieferimento Epidemiol & Prevenz Oncol Piemon, Turin, Italy; Univ Turin, Turin, Italy (författare)
Stephansson, OlofKarolinska Institutet (författare)
Cnattingius, SvenKarolinska Institutet (författare)
Ludvigsson, Jonas F.Karolinska Institutet,Region Örebro län,Clin Epidemiol Unit, Dept Med, Karolinska Inst, Stockholm, Sweden; Dept Pediat, Örebro University Hospital, Örebro, Sweden; Coll Med, Dept Med & Immunol, Div Gastroenterol & Hepatol, Mayo Clin, Rochester MN, USA(Swepub:oru)jsln (författare)
Karolinska InstitutetCanc Epidemiol Unit, Centrr Rieferimento Epidemiol & Prevenz Oncol Piemon, Turin, Italy; Univ Turin, Turin, Italy (creator_code:org_t)

Sammanhörande titlar

Ingår i:American Journal of Epidemiology: Oxford University Press177:12, s. 1348-13550002-92621476-6256

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Av författaren/redakt...: Zugna, Daniela; Richiardi, Loren ...; Stephansson, Olo ...; Cnattingius, Sve ...; Ludvigsson, Jona ...

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Av lärosätet: Örebro universitet; Karolinska Institutet

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