Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis

Gunaltay, Sezin,1986-Örebro universitet,Institutionen för medicinska vetenskaper (författare)

Funding Agency:Örebro University Hospital Research Foundation (Nyckelfonden)
One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation (FMT) in active collagenous colitis (CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT. The patient remained in remission for 11 mo after the third faecal transplantation. The immunomodulatory effect of the therapy was evaluated using flow cytometry, which showed alterations in the profile of intraepithelial and lamina propria lymphocyte subsets after the second transplantation. Our observations indicate that FMT can have an effect in CC, which support the hypothesis that luminal factors, influencing the intestinal microbiota, are involved in the pathogenesis of CC.

Rademacher, LechDivision of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden; Department of Medicine, Avesta Hospital, Avesta, Sweden (författare)
Hultgren Hörnquist, Elisabeth,1965-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)eht (författare)
Bohr, Johan,1957-Örebro universitet,Institutionen för hälsovetenskaper,Region Örebro län,Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)jbr (författare)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Ingår i:World Journal of Gastroenterology: Baishideng Publishing Group Co23:7, s. 1319-13241007-93272219-2840

Av författaren/redakt...: Gunaltay, Sezin, ...; Rademacher, Lech; Hultgren Hörnqui ...; Bohr, Johan, 195 ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

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