Search: id:"swepub:oai:DiVA.org:oru-57327" >
Evaluation of Mobil...
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Carlberg, MichaelRegion Örebro län,Department of Oncology, Örebro University Hospital, Örebro, Sweden
(author)
Evaluation of Mobile Phone and Cordless Phone Use and Glioma Risk Using the Bradford Hill Viewpoints from 1965 on Association or Causation
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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Hindawi Publishing Corporation,2017
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:oru-57327
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-57327URI
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https://doi.org/10.1155/2017/9218486DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Funding agencies:Cancerhjälpen Pandora-Foundation for Independent Research, Berlin, Germany
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Objective: Bradford Hill's viewpoints from 1965 on association or causation were used on glioma risk and use of mobile or cordless phones.Methods: All nine viewpoints were evaluated based on epidemiology and laboratory studies.Results: Strength: meta-analysis of case-control studies gave odds ratio (OR) = 1.90, 95% confidence interval (CI) = 1.31-2.76 with highest cumulative exposure. Consistency: the risk increased with latency, meta-analysis gave in the 10+ years' latency group OR = 1.62, 95% CI = 1.20-2.19. Specificity: increased risk for glioma was in the temporal lobe. Using meningioma cases as comparison group still increased the risk. Temporality: highest risk was in the 20+ years' latency group, OR = 2.01, 95% CI =1.41-2.88, for wireless phones. Biological gradient: cumulative use of wireless phones increased the risk. Plausibility: animal studies showed an increased incidence of glioma and malignant schwannoma in rats exposed to radiofrequency (RF) radiation. There is increased production of reactive oxygen species (ROS) from RF radiation. Coherence: there is a change in the natural history of glioma and increasing incidence. Experiment: antioxidants reduced ROS production from RF radiation. Analogy: there is an increased risk in subjects exposed to extremely low-frequency electromagnetic fields.Conclusion: RF radiation should be regarded as a human carcinogen causing glioma.
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Hardell, Lennart,1944-Region Örebro län,Department of Oncology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)lhl
(author)
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Region Örebro länDepartment of Oncology, Örebro University Hospital, Örebro, Sweden
(creator_code:org_t)
Related titles
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In:BioMed Research International: Hindawi Publishing Corporation20172314-61332314-6141
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