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  • Brander, GustafKarolinska Institutet (author)

Perinatal risk factors in Tourette's and chronic tic disorders : a total population sibling comparison study

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2017-03-28
  • Nature Publishing Group,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-57358
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-57358URI
  • https://doi.org/10.1038/mp.2017.31DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138214053URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:Karolinska Institutet PhD stipendDavid and Astrid Hagelen Foundation  Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM)  340-2013-5867 Indiana Clinical and Translational Sciences Institute: Pediatric Development Team  Shire 
  • Adverse perinatal events may increase the risk of Tourette's and chronic tic disorders (TD/CTD), but previous studies have been unable to control for unmeasured environmental and genetic confounding. We aimed to prospectively investigate potential perinatal risk factors for TD/CTD, taking unmeasured factors shared between full siblings into account. A population-based birth cohort, consisting of all singletons born in Sweden in 1973-2003, was followed until December 2013. A total of 3 026 861 individuals were identified, 5597 of which had a registered TD/CTD diagnosis. We then studied differentially exposed full siblings from 947 942 families; of these, 3563 families included siblings that were discordant for TD/CTD. Perinatal data were collected from the Medical Birth Register and TD/CTD diagnoses were collected from the National Patient Register, using a previously validated algorithm. In the fully adjusted models, impaired fetal growth, preterm birth, breech presentation and cesarean section were associated with a higher risk of TD/CTD, largely independent from shared family confounders and measured covariates. Maternal smoking during pregnancy was associated with risk of TD/CTD in a dose-response manner but the association was no longer statistically significant in the sibling comparison models or after the exclusion of comorbid attention-deficit/hyperactivity disorder. A dose-response relationship between the number of adverse perinatal events and increased risk for TD/CTD was also observed, with hazard ratios ranging from 1.41 (95% confidence interval (CI): 1.33-1.50) for one event to 2.42 (95% CI: 1.65-3.53) for five or more events. These results pave the way for future gene by environment interaction and epigenetic studies in TD/CTD.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rydell, MinaKarolinska Institutet (author)
  • Kuja-Halkola, RalfKarolinska Institutet (author)
  • Fernández de la Cruz, LorenaKarolinska Institutet (author)
  • Lichtenstein, Paul S.Karolinska Institutet (author)
  • Serlachius, EvaKarolinska Institutet (author)
  • Rück, ChristianKarolinska Institutet (author)
  • Almqvist, CatarinaKarolinska Institutet (author)
  • D'Onofrio, Brian M.Karolinska Institutet (author)
  • Larsson, Henrik,1975-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln (author)
  • Mataix-Cols, DavidKarolinska Institutet (author)
  • Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Molecular Psychiatry: Nature Publishing Group23:5, s. 1189-11971359-41841476-5578

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