Celiac disease is associated with childhood psychiatric disorders: A Population-Based Study

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Butwicka, AgnieszkaKarolinska Institutet (författare)

Celiac disease is associated with childhood psychiatric disorders : A Population-Based Study

Artikel/kapitelEngelska2017

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Elsevier,2017
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LIBRIS-ID:oai:DiVA.org:oru-57377
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-57377URI
https://doi.org/10.1016/j.jpeds.2017.01.043DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:135853663URI

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Språk:engelska
Sammanfattning på:engelska

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Anmärkningar

Funding agencies:Swedish Research Council 340-2013-5867, 523-2011-3807, 522-2009-1951Polish Ministry of Science and Higher Education 903/MOB/2012/0 and IP2012 006972Karolinska Institute FoundationMagnus Bergvall FoundationSwedish Society of MedicineSwedish Celiac SocietyEli-Lilly and Shire
OBJECTIVES: To determine the risk of future childhood psychiatric disorders in celiac disease, assess the association between previous psychiatric disorders and celiac disease in children, and investigate the risk of childhood psychiatric disorders in siblings of celiac disease probands.STUDY DESIGN: This was a nationwide registry-based matched cohort study in Sweden with 10 903 children (aged <18 years) with celiac disease and 12 710 of their siblings. We assessed the risk of childhood psychiatric disorders (any psychiatric disorder, psychotic disorder, mood disorder, anxiety disorder, eating disorder, psychoactive substance misuse, behavioral disorder, attention-deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and intellectual disability). HRs of future psychiatric disorders in children with celiac disease and their siblings was estimated by Cox regression. The association between previous diagnosis of a psychiatric disorder and current celiac disease was assessed using logistic regression.RESULTS: Compared with the general population, children with celiac disease had a 1.4-fold greater risk of future psychiatric disorders. Childhood celiac disease was identified as a risk factor for mood disorders, anxiety disorders, eating disorders, behavioral disorders, ADHD, ASD, and intellectual disability. In addition, a previous diagnosis of a mood, eating, or behavioral disorder was more common before the diagnosis of celiac disease. In contrast, siblings of celiac disease probands were at no increased risk of any of the investigated psychiatric disorders.CONCLUSIONS: Children with celiac disease are at increased risk for most psychiatric disorders, apparently owing to the biological and/or psychological effects of celiac disease.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
attention-deficit hyperactivity disorder
autism
celiac disease
psychiatric disorder
Immunology
Immunologi

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lichtenstein, PaulKarolinska Institutet (författare)
Frisén, LouiseKarolinska Institutet (författare)
Almqvist, CatarinaKarolinska Institutet (författare)
Larsson, Henrik,1975-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden(Swepub:oru)hiln (författare)
Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, United States(Swepub:oru)jsln (författare)
Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Pediatrics: Elsevier184, s. 87-93.e10022-34761097-6833

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Av författaren/redakt...: Butwicka, Agnies ...; Lichtenstein, Pa ...; Frisén, Louise; Almqvist, Catari ...; Larsson, Henrik, ...; Ludvigsson, Jona ...

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