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Metabolic and infla...
Metabolic and inflammatory responses and subsequent recovery in robotic versus abdominal hysterectomy : A randomised controlled study
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- Wijk, Lena, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Obstetrics and Gynaecology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Nilsson, Kerstin, 1953- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Ljungqvist, Olle, 1954- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- English.
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In: Clinical Nutrition. - : Elsevier. - 0261-5614 .- 1532-1983. ; 37:1, s. 99-106
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Abstract
Subject headings
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- BACKGROUND & AIMS: Surgery causes inflammatory and metabolic responses in the body. The aim of the study was to investigate whether robotic-assisted total laparoscopic hysterectomy induces less insulin resistance than abdominal hysterectomy, and to compare inflammatory response and clinical recovery between the two techniques.METHODS: A randomised controlled study at the Department of Obstetrics and Gynaecology, Örebro University Hospital, Sweden. Twenty women scheduled for a planned total hysterectomy with or without salpingo-oophorectomy between October 2014 and May 2015, were randomly allocated to robotic-assisted total laparoscopic hysterectomy or abdominal hysterectomy. Insulin resistance after surgery was measured by the hyperinsulinemic normoglycaemic clamp method, inflammatory response measured in blood samples, and clinical recovery outcomes registered.RESULTS: There were no differences in development of insulin resistance between the robotic group and the abdominal group (mean ± SD: 39% ± 22 vs. 40% ± 19; p = 0.948). The robotic group had a significantly shorter hospital stay (median 1 vs. 2 days; p = 0.005). Inflammatory reaction differed; in comparison to the robotic group, the abdominal group showed significantly higher increases in serum interleukin 6 levels, white blood cell count and cortisol from preoperative values to postoperative peak values.CONCLUSIONS: Robotic laparoscopic surgery reduced inflammatory responses and recovery time, but these changes were not accompanied by decreased insulin resistance.CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov Identifier no NCT02291406.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Robotic-assisted hysterectomy; Insulin resistance; Hysterectomy; Inflammatory response
- Obstetrik och gynekologi
- Obstetrics and Gynaecology
Publication and Content Type
- ref (subject category)
- art (subject category)
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