Appropriate Time for Test-of-Cure when Diagnosing Gonorrhoea with a Nucleic Acid Amplification Test

Hjelmevoll, Stig OveDepartments of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway (author)

Funding Agency:Department of Microbiology at the University Hospital of North Norway, Tromso, Norway
Culture is commonly regarded as the gold standard for diagnosis of Neisseria gonorrhoeae. However, nucleic acid amplification tests (NAATs) have rapidly replaced culture for diagnostics in many settings. The aim of the present study was to investigate the appropriate time for test-of-cure (TOC) when NAATs are used for diagnosis of gonorrhoea. In total, 30 patients (28 men and 2 women) provided urethral, cervical, rectal or pharyngeal specimens for TOC. All included patients, except one who did not return for second TOC before day 19, tested negative within 2 weeks after treatment with cefixime 400 mg x 1. Antimicrobial susceptibility testing showed that 68% of the culture-positive strains were resistant to ciprofloxacin. Thus, the recommended empirical treatment with ciprofloxacin in Norway should be changed immediately. TOC can be performed 2 weeks after treatment when NAATs are used for diagnosis of gonorrhoea.

Olsen, Merethe EliseDepartments of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway (author)
Sollid, Johanna U. EricsonDepartment of Microbiology and Virology, Institute of Medical Biology, University Hospital of North Norway, Tromsø, Norway (author)
Haaheim, HakonDepartments of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway (author)
Melby, Kjetil K.Department of Microbiology, Oslo University Hospital Ullevål, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway (author)
Moi, HaraldOlafiaklinikken, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway (author)
Unemo, Magnus,1970-Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other STIs, National Reference Laboratory for Pathogenic Neisseria, Örebro University Hospital, Örebro, Sverige; Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)muo (author)
Skogen, VegardDepartments of Infectious Diseases, Medical Clinic, University Hospital of North Norway, Tromsø, Norway; Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway (author)
Departments of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, NorwayDepartment of Microbiology and Virology, Institute of Medical Biology, University Hospital of North Norway, Tromsø, Norway (creator_code:org_t)

In:Acta Dermato-VenereologicaUppsala : Acta Dermato-Venereologica92:3, s. 316-3190001-55551651-2057

By the author/editor: Hjelmevoll, Stig ...; Olsen, Merethe E ...; Sollid, Johanna ...; Haaheim, Hakon; Melby, Kjetil K.; Moi, Harald; show more...; Unemo, Magnus, 1 ...; Skogen, Vegard; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Clinical Laborat ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

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