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CRP, C-Peptide, and...
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Gedebjerg, AnneAarhus University Hospital
(author)
CRP, C-Peptide, and Risk of First-Time Cardiovascular Events and Mortality in Early Type 2 Diabetes : A Danish Cohort Study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-03-17
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American Diabetes Association,2023
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9 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:82e190ae-d8ba-4d11-9891-0a07d4279f50
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https://lup.lub.lu.se/record/82e190ae-d8ba-4d11-9891-0a07d4279f50URI
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https://doi.org/10.2337/dc22-1353DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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We investigated the relationship between hs-CRP, a marker of low-grade inflam-mation, alone or in combination with C-peptide, a marker of hyperinsulinemia/ insulin resistance, and risk for cardiovascular events (CVEs) and mortality in patients recently diagnosed with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In patients with recent-onset T2D, we measured serum hs-CRP (n = 7,301) and C-peptide (n = 5,765) in the prospective Danish Centre for Strategic Research in Type 2 Diabetes cohort study. Patients with no prior CVE (n = 6,407) were followed until first myocardial infarction, stroke, coronary revascularization, or cardiovascular death, and all patients (n = 7,301) were followed for all-cause mortality. We com-puted adjusted hazard ratios (aHRs) by Cox regression and tested for the interaction between hs-CRP and C-peptide. RESULTS During follow-up (median 4.8 years), high (>3 mg/L) versus low (<1 mg/L) hs-CRP was associated with increased CVE risk (aHR 1.45 [95% CI 1.07–1.96]) and with even greater risk of all-cause mortality (2.47 [1.88–3.25]). Compared with patients with low hs-CRP (£3 mg/L) and low C-peptide (<1,470 pmol/L), those with high lev-els of both biomarkers had the highest CVE (1.61 [1.10–2.34]) and all-cause mortality risk (2.36 [1.73–3.21]). Among patients with high C-peptide, risk of CVEs did not differ by low or high hs-CRP, whereas risk of all-cause mortality did. CONCLUSIONS The finding of high hs-CRP as a stronger prognostic biomarker of all-cause mortality than of CVEs may facilitate improved early detection and prevention of deadly diseases besides CVEs. Conversely, elevated C-peptide as a strong CVE biomarker sup-ports the need to target hyperinsulinemia/insulin resistance in T2D CVE prevention.
Subject headings and genre
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Bjerre, MetteAarhus University
(author)
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Kjaergaard, Alisa DevedzicAarhus University Hospital
(author)
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Nielsen, Jens SteenOdense University Hospital
(author)
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Rungby, JørgenBispebjerg Hospital,Steno Diabetes Center Copenhagen
(author)
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Brandslund, IvanVejle Hospital
(author)
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Maeng, MichaelAarhus University Hospital
(author)
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Beck-Nielsen, HenningOdense University Hospital
(author)
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Vaag, AllanLund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Steno Diabetes Center Copenhagen(Swepub:lu)med-ava
(author)
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Sørensen, Henrik ToftAarhus University Hospital
(author)
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Hansen, Troels KrarupAarhus University Hospital
(author)
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Thomsen, Reimar WernichAarhus University Hospital
(author)
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Aarhus University HospitalAarhus University
(creator_code:org_t)
Related titles
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In:Diabetes Care: American Diabetes Association46:5, s. 1037-10450149-59921935-5548
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Gedebjerg, Anne
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Bjerre, Mette
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Kjaergaard, Alis ...
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Nielsen, Jens St ...
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Rungby, Jørgen
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Brandslund, Ivan
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Maeng, Michael
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Beck-Nielsen, He ...
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Vaag, Allan
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Sørensen, Henrik ...
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Hansen, Troels K ...
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Thomsen, Reimar ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Diabetes Care
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Lund University