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  • Gedebjerg, AnneAarhus University Hospital (author)

CRP, C-Peptide, and Risk of First-Time Cardiovascular Events and Mortality in Early Type 2 Diabetes : A Danish Cohort Study

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-03-17
  • American Diabetes Association,2023
  • 9 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:82e190ae-d8ba-4d11-9891-0a07d4279f50
  • https://lup.lub.lu.se/record/82e190ae-d8ba-4d11-9891-0a07d4279f50URI
  • https://doi.org/10.2337/dc22-1353DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • We investigated the relationship between hs-CRP, a marker of low-grade inflam-mation, alone or in combination with C-peptide, a marker of hyperinsulinemia/ insulin resistance, and risk for cardiovascular events (CVEs) and mortality in patients recently diagnosed with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In patients with recent-onset T2D, we measured serum hs-CRP (n = 7,301) and C-peptide (n = 5,765) in the prospective Danish Centre for Strategic Research in Type 2 Diabetes cohort study. Patients with no prior CVE (n = 6,407) were followed until first myocardial infarction, stroke, coronary revascularization, or cardiovascular death, and all patients (n = 7,301) were followed for all-cause mortality. We com-puted adjusted hazard ratios (aHRs) by Cox regression and tested for the interaction between hs-CRP and C-peptide. RESULTS During follow-up (median 4.8 years), high (>3 mg/L) versus low (<1 mg/L) hs-CRP was associated with increased CVE risk (aHR 1.45 [95% CI 1.07–1.96]) and with even greater risk of all-cause mortality (2.47 [1.88–3.25]). Compared with patients with low hs-CRP (£3 mg/L) and low C-peptide (<1,470 pmol/L), those with high lev-els of both biomarkers had the highest CVE (1.61 [1.10–2.34]) and all-cause mortality risk (2.36 [1.73–3.21]). Among patients with high C-peptide, risk of CVEs did not differ by low or high hs-CRP, whereas risk of all-cause mortality did. CONCLUSIONS The finding of high hs-CRP as a stronger prognostic biomarker of all-cause mortality than of CVEs may facilitate improved early detection and prevention of deadly diseases besides CVEs. Conversely, elevated C-peptide as a strong CVE biomarker sup-ports the need to target hyperinsulinemia/insulin resistance in T2D CVE prevention.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bjerre, MetteAarhus University (author)
  • Kjaergaard, Alisa DevedzicAarhus University Hospital (author)
  • Nielsen, Jens SteenOdense University Hospital (author)
  • Rungby, JørgenBispebjerg Hospital,Steno Diabetes Center Copenhagen (author)
  • Brandslund, IvanVejle Hospital (author)
  • Maeng, MichaelAarhus University Hospital (author)
  • Beck-Nielsen, HenningOdense University Hospital (author)
  • Vaag, AllanLund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Steno Diabetes Center Copenhagen(Swepub:lu)med-ava (author)
  • Sørensen, Henrik ToftAarhus University Hospital (author)
  • Hansen, Troels KrarupAarhus University Hospital (author)
  • Thomsen, Reimar WernichAarhus University Hospital (author)
  • Aarhus University HospitalAarhus University (creator_code:org_t)

Related titles

  • In:Diabetes Care: American Diabetes Association46:5, s. 1037-10450149-59921935-5548

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