Genetic and environmental contributions to the association between ADHD and affective problems in early childhood: A Swedish population-based twin study

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MARC

Rydell, MinaKarolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (author)

Genetic and environmental contributions to the association between ADHD and affective problems in early childhood : A Swedish population-based twin study

Article/chapterEnglish2017

Publisher, publication year, extent ...

2017-04-24
Stockholm :John Wiley & Sons,2017
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:oru-58944
ISSN:1552-4841
10616/45980hdl
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-58944URI
https://doi.org/10.1002/ajmg.b.32536DOI
http://hdl.handle.net/10616/45980URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:136016970URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Few twin studies have explored the relative contribution of genetic and environmental factors to the association between attention deficit hyperactivity disorder (ADHD) and affective problems, and no study has focused on preschool children. We used the classical twin design to explore the genetic and environmental overlap between ADHD symptoms and affective problems in preschool children, based on 879 five-year-old twin pairs born in Sweden 2004-2005. Questionnaire-based parent-ratings were used to measure ADHD symptoms and affective problems. A bivariate twin design was used to decompose variance in ADHD and affective problems into genetic and environmental components, and to test the degree to which these components overlapped across the two traits. Our results showed that there was a significant correlation of 0.34 (95% Confidence Interval [CI] 0.29-0.38) between ADHD and affective problems. This correlation was mostly explained by additive genetic factors (64%, 95%CI 37-93%), and to a lesser extent by shared environmental factors (35%, 95%CI 10-59%). Nonshared environmental factors did not contribute to the correlation between ADHD and affective problems (0%, 95%CI -9 to 10%). These findings show that there is a significant association between ADHD and affective problems in preschool children that is mostly explained by genetic influences. This adds important knowledge about the etiology of both ADHD and affective problems by indicating that these phenotypes are linked from as early as preschool years. This also needs to be taken into consideration when diagnosing young children and clinicians should consider assessing both affective problems and ADHD if one is present.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
NATURVETENSKAP Biologi Genetik hsv//swe
NATURAL SCIENCES Biological Sciences Genetics hsv//eng
ADHD
affective problems
comorbidity
twin study
Genetik
Genetics

Added entries (persons, corporate bodies, meetings, titles ...)

Taylor, Mark J.Karolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (author)
Larsson, Henrik,1975-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln (author)
Karolinska InstitutetDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)
Karolinska Institutet
Karolinska Institutet

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In:American Journal of Medical Genetics Part BStockholm : John Wiley & Sons174:5, s. 538-5461552-48411552-485X

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Genetics

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By the university: Örebro University; Karolinska Institutet

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