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Dysregulation of li...
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
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- Oresic, Matej, 1967- (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Simell, Satu (författare)
- Department of Pediatrics, University of Turku, Turku, Finland
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- Sysi-Aho, Marko (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Näntö-Salonen, Kirsti (författare)
- Department of Pediatrics, University of Turku, Turku, Finland
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- Seppänen-Laakso, Tuulikki (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Parikka, Vilhelmiina (författare)
- Department of Pediatrics, University of Turku, Turku, Finland
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- Katajamaa, Mikko (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Hekkala, Anne (författare)
- Department of Pediatrics, University of Oulu, Oulu, Finland
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- Mattila, Ismo (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Keskinen, Päivi (författare)
- Department of Pediatrics, Tampere University Hospital, Tampere, Finland
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- Yetukuri, Laxman (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Reinikainen, Arja (författare)
- Turku Centre for Biotechnology, Turku, Finland
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- Lähde, Jyrki (författare)
- Department of Pediatrics, Tampere University Hospital, Tampere, Finland
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- Suortti, Tapani (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Hakalax, Jari (författare)
- Department of Pediatrics, University of Turku, Turku, Finland
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- Simell, Tuula (författare)
- Department of Pediatrics, University of Turku, Turku, Finland
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- Hyöty, Heikki (författare)
- Department of Virology, University of Tampere, Tampere, Finland; Centre for Laboratory Medicine, University Hospital of Tampere, Tampere, Finland
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- Veijola, Riitta (författare)
- Department of Pediatrics, University of Oulu, Oulu, Finland
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- Ilonen, Jorma (författare)
- Department of Clinical Microbiology, University of Kuopio, Kuopio, Finland
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- Lahesmaa, Riitta (författare)
- Turku Centre for Biotechnology, Turku, Finland
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- Knip, Mikael (författare)
- Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
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- Simell, Olli (författare)
- Department of Pediatrics, University of Turku, Turku, Finland
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(creator_code:org_t)
- 2008-12-15
- 2008
- Engelska.
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Ingår i: Journal of Experimental Medicine. - New York, USA : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 205:13, s. 2975-2984
- Relaterad länk:
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http://jem.rupress.o...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward beta cell failure, and factors determining time of presentation of clinical diabetes are poorly understood. We investigated changes in the serum metabolome prospectively in children who later progressed to type 1 diabetes. Serum metabolite profiles were compared between sample series drawn from 56 children who progressed to type 1 diabetes and 73 controls who remained nondiabetic and permanently autoantibody negative. Individuals who developed diabetes had reduced serum levels of succinic acid and phosphatidylcholine (PC) at birth, reduced levels of triglycerides and antioxidant ether phospholipids throughout the follow up, and increased levels of proinflammatory lysoPCs several months before seroconversion to autoantibody positivity. The lipid changes were not attributable to HLA-associated genetic risk. The appearance of insulin and glutamic acid decarboxylase autoantibodies was preceded by diminished ketoleucine and elevated glutamic acid. The metabolic profile was partially normalized after the seroconversion. Autoimmunity may thus be a relatively late response to the early metabolic disturbances. Recognition of these preautoimmune alterations may aid in studies of disease pathogenesis and may open a time window for novel type 1 diabetes prevention strategies.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
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Oresic, Matej, 1 ...
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Simell, Satu
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Sysi-Aho, Marko
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Näntö-Salonen, K ...
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Seppänen-Laakso, ...
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Parikka, Vilhelm ...
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Katajamaa, Mikko
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Hekkala, Anne
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Mattila, Ismo
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Keskinen, Päivi
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Yetukuri, Laxman
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Reinikainen, Arj ...
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Lähde, Jyrki
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Suortti, Tapani
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Hakalax, Jari
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Simell, Tuula
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Hyöty, Heikki
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Veijola, Riitta
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Ilonen, Jorma
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Lahesmaa, Riitta
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Knip, Mikael
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Simell, Olli
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