Modeling strategies to study metabolic pathways in progression to type 1 diabetes: Challenges and opportunities

Modeling strategies to study metabolic pathways in progression to type 1 diabetes : Challenges and opportunities

Funding Agencies:Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research, Projektnr. 250114Juvenile Diabetes Research Foundation, Projektnr. 2-SRA-2014-159-Q-R
Seroconversion to islet autoimmunity is preceded by metabolic disturbances in children who later progress to overt type 1 diabetes (T1D). The underlying metabolic pathways and the interaction of metabolic and immune system factors involved in progression to the disease are however poorly understood. There is a clear need for mathematical models which capture the temporal and spatial complexity of early pathogenesis of T1D. Here we review the early attempts to model the development of islet autoimmunity and T1D, including the models which emphasize the potential beneficial role of autoimmune response in specific circumstances, such as to 'correct' for the early metabolic disturbances. We also highlight the genome-scale metabolic modeling as a promising new avenue to study metabolism and its interactions with the immune system in T1D.

Oresic, Matej,1967-Steno Diabetes Center A/S, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc (författare)
Steno Diabetes Center A/S, Gentofte, DenmarkSteno Diabetes Center A/S, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland (creator_code:org_t)

Ingår i:Archives of Biochemistry and BiophysicsMaryland Heights, MO, USA : Academic Press589, s. 131-70003-98611096-0384

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