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  • Lankinen, MariaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland. (författare)

A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • New York, USA :Oxford University Press,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-59368
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-59368URI
  • https://doi.org/10.3945/jn.115.220459DOI
  • https://lup.lub.lu.se/record/8852770URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-295554URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:NordForsk (SYSDIET), Projektnr. 070014 Academy of Finland Finnish Diabetes Research Foundation Finnish Foundation for Cardiovascular Research Sigfrid Juselius Foundation Kuopio University Hospital Finnish Cultural Foundation North-Savo Regional Fund Paavo Nurmi Foundation (Finland) Druvan FoundationESPENSkane County Council Research and Development FoundationDiabetesfonden and Foundation Cerealia (Sweden)Danish Obesity Research Centre (DanORC) Danish Council for Strategic Research (Dairy-Health, BioFunCarb) (Denmark)Agricultural Productivity Fund Research Fund of University of Iceland (Iceland) 
  • BACKGROUND: A healthy Nordic diet is associated with improvements in cardiometabolic risk factors, but the effect on lipidomic profile is not known.OBJECTIVE: The aim was to investigate how a healthy Nordic diet affects the fasting plasma lipidomic profile in subjects with metabolic syndrome.METHODS: Men and women (n = 200) with features of metabolic syndrome [mean age: 55 y; body mass index (in kg/m(2)): 31.6] were randomly assigned to either a healthy Nordic (n = 104) or a control (n = 96) diet for 18 or 24 wk at 6 centers. Of the participants, 156 completed the study with plasma lipidomic measurements. The healthy Nordic diet consisted of whole grains, fruits, vegetables, berries, vegetable oils and margarines, fish, low-fat milk products, and low-fat meat. An average Nordic diet served as the control diet and included low-fiber cereal products, dairy fat-based spreads, regular-fat milk products, and a limited amount of fruits, vegetables, and berries. Lipidomic profiles were measured at baseline, week 12, and the end of the intervention (18 or 24 wk) by using ultraperformance liquid chromatography mass spectrometry. The effects of the diets on the lipid variables were analyzed with linear mixed-effects models. Data from centers with 18- or 24-wk duration were also analyzed separately.RESULTS: Changes in 21 plasma lipids differed significantly between the groups at week 12 (false discovery rate P < 0.05), including increases in plasmalogens and decreases in ceramides in the healthy Nordic diet group compared with the control group. At the end of the study, changes in lipidomic profiles did not differ between the groups. However, when the intervention lasted 24 wk, changes in 8 plasma lipids that had been identified at 12 wk, including plasmalogens, were sustained. There were no differences in changes in plasma lipids between groups with an intervention of 18 wk. By the dietary biomarker score, adherence to diet did not explain the difference in the results related to the duration of the study.CONCLUSIONS: A healthy Nordic diet transiently modified the plasma lipidomic profile, specifically by increasing the concentrations of antioxidative plasmalogens and decreasing insulin resistance-inducing ceramides. This trial was registered at clinicaltrials.gov as NCT00992641.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Schwab, UrsulaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;Kuopio Univ Hosp, Inst Clin Med, Internal Med, SF-70210 Kuopio, Finland. (författare)
  • Kolehmainen, MarjukkaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland. (författare)
  • Paananen, JussiInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Biomed, Kuopio, Finland. (författare)
  • Nygren, HeliVTT Technical Research Centre of Finland, Espoo, Finland,VTT Tech Res Ctr Finland, Espoo, Finland. (författare)
  • Seppänen-Laakso, TuulikkiVTT Technical Research Centre of Finland, Espoo, Finland,VTT Tech Res Ctr Finland, Espoo, Finland. (författare)
  • Poutanen, KaisaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;VTT Tech Res Ctr Finland, Espoo, Finland. (författare)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark,VTT Tech Res Ctr Finland, Espoo, Finland.;Steno Diabet Ctr, DK-2820 Gentofte, Denmark.(Swepub:oru)tihn (författare)
  • Risérus, UlfUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (författare)
  • Savolainen, Markku J.Research Center for Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Internal Medicine, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland,Univ Oulu, Res Ctr Internal Med & Bioctr Oulu, Oulu, Finland.;Oulu Univ Hosp, Dept Internal Med, Oulu, Finland.;Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.;Univ Oulu, Oulu, Finland. (författare)
  • Hukkanen, JanneResearch Center for Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Internal Medicine, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland,Univ Oulu, Res Ctr Internal Med & Bioctr Oulu, Oulu, Finland.;Oulu Univ Hosp, Dept Internal Med, Oulu, Finland.;Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.;Univ Oulu, Oulu, Finland. (författare)
  • Brader, LeaDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, DK-8000 Aarhus, Denmark. (författare)
  • Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)matma701 (författare)
  • Rosqvist, FredrikUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)frero353 (författare)
  • Hermansen, KjeldDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, DK-8000 Aarhus, Denmark. (författare)
  • Cloetens, LieselotteLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Biomed Nutr Pure & Appl Biochem, Lund, Sweden.(Swepub:lu)tbio-lce (författare)
  • Önning, GunillaLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Biomed Nutr Pure & Appl Biochem, Lund, Sweden.(Swepub:lu)inl-gon (författare)
  • Thorsdottir, IngaUnit for Nutrition Research, Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, , Reykjavik, Iceland; Landspitali – University Hospital, Reykjavik, Iceland,Univ Iceland, Sch Hlth Sci, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland.;Landspitali Univ Hosp, Reykjavik, Iceland. (författare)
  • Gunnarsdottir, IngibjorgUnit for Nutrition Research, Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, , Reykjavik, Iceland; Landspitali – University Hospital, Reykjavik, Iceland,Univ Iceland, Sch Hlth Sci, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland.;Landspitali Univ Hosp, Reykjavik, Iceland. (författare)
  • Åkesson, BjörnLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Biomed Nutr Pure & Appl Biochem, Lund, Sweden.;Skane Univ Hosp, Dept Clin Nutr, Lund, Sweden.(Swepub:lu)kc-bak (författare)
  • Dragsted, Lars OveFaculty of Science, Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark,Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Frederiksberg, Denmark. (författare)
  • Uusitupa, MattiInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Research Unit, Kuopio University Hospital, Kuopio, Finland;,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;Kuopio Univ Hosp, Res Unit, SF-70210 Kuopio, Finland. (författare)
  • Orešič, Matej,1967-VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark,VTT Tech Res Ctr Finland, Espoo, Finland.;Steno Diabet Ctr, DK-2820 Gentofte, Denmark.(Swepub:oru)moc (författare)
  • Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, FinlandUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of NutritionNew York, USA : Oxford University Press146:4, s. 662-6720022-31661541-6100

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