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  • Jørgenrud, BenedicteDepartment of Pediatric Research, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway; Hormone Laboratory, Department of Medical Biochemistry, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway (författare)

Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2016-01-21
  • Wiley-Blackwell Publishing Inc.2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-59387
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-59387URI
  • https://doi.org/10.1111/pedi.12360DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agency:Research Council of Norway  214191  166515/V50
  • AIMS: The aim of this study was to investigate the longitudinal plasma metabolic profiles in healthy infants and the potential association with breastfeeding duration and islet autoantibodies predictive of type 1 diabetes.METHOD: Up to four longitudinal plasma samples from age 3 months from case children who developed islet autoimmunity (n = 29) and autoantibody-negative control children (n = 29) with the HLA DR4-DQ8/DR3-DQ2 genotype were analyzed using two-dimensional gas chromatography coupled to a time-of-flight mass spectrometer for detection of small polar metabolites.RESULTS: Plasma metabolite levels were found to depend strongly on age, with fold changes varying up to 50% from age 3 to 24 months (p < 0.001 after correction for multiple testing). Tyrosine levels tended to be lower in case children, but this was not significant after correction for multiple testing. Ornithine levels were lower in case children compared with the controls at the time of seroconversion, but the difference was not statistically significant after correcting for multiple testing. Breastfeeding for at least 3 months as compared with shorter duration was associated with higher plasma levels of isoleucine, and lower levels of methionine and 3,4-dihydroxybutyric acid at 3 months of age.CONCLUSIONS: Plasma levels of several small, polar metabolites changed with age during early childhood, independent of later islet autoimmunity status and sex. Breastfeeding was associated with higher levels of branched-chain amino acids, and lower levels of methionine and 3,4-dihydroxybutyric acid.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Stene, Lars CDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway (författare)
  • Tapia, GermanDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway (författare)
  • Bøås, HåkonDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway (författare)
  • Pepaj, MilaimHormone Laboratory, Department of Medical Biochemistry, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway (författare)
  • Berg, Jens PDivision of Diagnostic and Intervention, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway (författare)
  • Thorsby, Per MHormone Laboratory, Department of Medical Biochemistry, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway (författare)
  • Orešič, Matej,1967-Systems Medicine Department, Steno Diabetes Centre, Gentofte, Denmark; VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc (författare)
  • Hyötyläinen, Tuulia,1971-Systems Medicine Department, Steno Diabetes Centre, Gentofte, Denmark; VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)tihn (författare)
  • Rønningen, Kjersti SDepartment of Pediatric Research, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway (författare)
  • Department of Pediatric Research, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway; Hormone Laboratory, Department of Medical Biochemistry, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, NorwayDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Pediatric Diabetes: Wiley-Blackwell Publishing Inc.18:2, s. 111-1191399-543X1399-5448

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