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Hypothalamic AMPK-E...
Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
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- Martínez-Sánchez, Noelia (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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- Seoane-Collazo, Patricia (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesid
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- Contreras, Cristina (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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- Varela, Luis (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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- Villarroya, Joan (författare)
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina, Universitat de Barcelona (IBUB), Barcelona, Spain; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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- Rial-Pensado, Eva (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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- Buqué, Xabier (författare)
- Department of Physiology, University of the Basque Country UPV/EHU, Biocruces Research Institute, Barakaldo, Spain
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- Aurrekoetxea, Igor (författare)
- Department of Physiology, University of the Basque Country UPV/EHU, Biocruces Research Institute, Barakaldo, Spain
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- Delgado, Teresa C. (författare)
- CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain
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- Vázquez-Martínez, Rafael (författare)
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, Spain
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- González-García, Ismael (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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- Roa, Juan (författare)
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, Spain
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- Whittle, Andrew J. (författare)
- University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
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- Gomez-Santos, Beatriz (författare)
- Department of Physiology, University of the Basque Country UPV/EHU, Biocruces Research Institute, Barakaldo, Spain
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- Velagapudi, Vidya (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland; Metabolomics Unit, Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland
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- Tung, Y. C. Loraine (författare)
- University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
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- Morgan, Donald A. (författare)
- Department of Pharmacology, University of Iowa, Iowa City, USA
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- Voshol, Peter J. (författare)
- University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
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- Martínez de Morentin, Pablo B. (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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- López-González, Tania (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
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- Liñares-Pose, Laura (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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- Gonzalez, Francisco (författare)
- Department of Surgery, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; Service of Ophthalmology, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain
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- Chatterjee, Krishna (författare)
- University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
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- Sobrino, Tomás (författare)
- Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
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- Medina-Gómez, Gema (författare)
- Department of Basic Sciences of Health, Area of Biochemistry and Molecular Biology, University Rey Juan Carlos, Madrid, Spain
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- Davis, Roger J. (författare)
- Program in Molecular Medicine, University of Massachusetts Medical School, Worcester MA, USA; Howard Hughes Medical Institute, Worcester MA, USA
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- Casals, Núria (författare)
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Sant Cugat del Vallés, Barcelona, Spain
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- Oresic, Matej, 1967- (författare)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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- Coll, Anthony P. (författare)
- University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
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- Vidal-Puig, Antonio (författare)
- University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
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- Mittag, Jens (författare)
- Internal Medicine I, Center of Brain, Behavior, and Metabolism (CBBM), University of Lübeck, Lübeck, Germany
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- Tena-Sempere, Manuel (författare)
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, Spain; FiDiPro Program, Department of Physiology, University of Turku, Turku, Finland
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- Malagón, María M. (författare)
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, Spain
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- Diéguez, Carlos (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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- Martínez-Chantar, María Luz (författare)
- CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Technology Park of Bizkaia, Derio, Bizkaia, Spain
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- Aspichueta, Patricia (författare)
- Department of Physiology, Biocruces Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHU, Barakaldo, Spain
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- Rahmouni, Kamal (författare)
- Department of Pharmacology, University of Iowa, Iowa City IA, USA; Department of Internal Medicine, University of Iowa, Iowa City IA, USA
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- Nogueiras, Rubén (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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- Sabio, Guadalupe (författare)
- Myocardial Pathophysiology, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain
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- Villarroya, Francesc (författare)
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina, Universitat de Barcelona (IBUB), Barcelona, Spain
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- López, Miguel (författare)
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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(creator_code:org_t)
- Cambridge, MA, United States : Cell Press, 2017
- 2017
- Engelska.
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Ingår i: Cell Metabolism. - Cambridge, MA, United States : Cell Press. - 1550-4131 .- 1932-7420. ; 26:1, s. 212-229.e12
- Relaterad länk:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) through the parasympathetic (PSNS) and sympathetic nervous system (SNS), respectively. Central T3 promotes hepatic lipogenesis with parallel stimulation of the thermogenic program in BAT. The action of T3 depends on AMP-activated protein kinase (AMPK)-induced regulation of two signaling pathways in the ventromedial nucleus of the hypothalamus (VMH): decreased ceramide-induced endoplasmic reticulum (ER) stress, which promotes BAT thermogenesis, and increased c-Jun N-terminal kinase (JNK) activation, which controls hepatic lipid metabolism. Of note, ablation of AMPKα1 in steroidogenic factor 1 (SF1) neurons of the VMH fully recapitulated the effect of central T3, pointing to this population in mediating the effect of central THs on metabolism. Overall, these findings uncover the underlying pathways through which central T3 modulates peripheral metabolism.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- AMPK
- BAT
- ER stress
- JNK1
- SF1
- VMH
- autonomic nervous system
- ceramides
- liver
- thyroid hormones
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Martínez-Sánchez ...
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Seoane-Collazo, ...
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Contreras, Crist ...
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Varela, Luis
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Villarroya, Joan
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Rial-Pensado, Ev ...
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visa fler...
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Buqué, Xabier
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Aurrekoetxea, Ig ...
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Delgado, Teresa ...
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Vázquez-Martínez ...
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González-García, ...
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Roa, Juan
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Whittle, Andrew ...
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Gomez-Santos, Be ...
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Velagapudi, Vidy ...
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Tung, Y. C. Lora ...
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Morgan, Donald A ...
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Voshol, Peter J.
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Martínez de More ...
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López-González, ...
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Liñares-Pose, La ...
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Gonzalez, Franci ...
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Chatterjee, Kris ...
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Sobrino, Tomás
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Medina-Gómez, Ge ...
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Davis, Roger J.
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Casals, Núria
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Oresic, Matej, 1 ...
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Coll, Anthony P.
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Vidal-Puig, Anto ...
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Mittag, Jens
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Tena-Sempere, Ma ...
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Malagón, María M ...
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Diéguez, Carlos
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Martínez-Chantar ...
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Aspichueta, Patr ...
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Rahmouni, Kamal
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Nogueiras, Rubén
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Sabio, Guadalupe
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Villarroya, Fran ...
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López, Miguel
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Cell Metabolism
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Örebro universitet