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Sökning: (WFRF:(Ludvigsson J)) pers:(Ludvigsson Jonas F.) > (2015-2019) > Anti-TNF treatment ...

  • Eberhardson, M.Karolinska Institutet (författare)

Anti-TNF treatment in Crohn's disease and risk of bowel resection-a population based cohort study

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-07-28
  • John Wiley & Sons,2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-60590
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-60590URI
  • https://doi.org/10.1111/apt.14224DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333957URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-140500URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136403943URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Bengt Ihre Research Fellowship  Ihre Grant  Stockholm County Council ALF  Swedish Medical Society (Projektmedel)  Swedish Medical Society (Gastroenterologisk forskningsfond)  Swedish Medical Society (Ihre fonden)  Mjölkdroppen Foundation  Jane and Dan Olsson Foundation  Magtarmfonden  Stockholm County Council ALF project  LS1211-1460  LS2015-1198 
  • Funding Agencies|Bengt Ihre Research Fellowship; Ihre Grant; Stockholm County Council ALF; Swedish Medical Society (Projektmedel); Swedish Medical Society (Gastroenterologisk forskningsfond); Swedish Medical Society (Ihre fonden); Mjolkdroppen Foundation; Jane and Dan Olsson Foundation; Magtarmfonden; Stockholm County Council ALF project [LS1211-1460, LS2015-1198]
  • Background: TNF inhibitors (TNFi) have been shown to reduce the need for surgery in Crohn's disease, but few studies have examined their effect beyond the first year of treatment.Aim: To conduct a register-based observational cohort study in Sweden 2006-2014 to investigate the risk of bowel resection in bowel surgery naive TNFi-treated Crohn's disease patients and whether patients on TNFi >= 12 months are less likely to undergo bowel resection than patients discontinuing treatment before 12 months.Methods: We identified all individuals in Sweden with Crohn's disease through the Swedish National Patient Register 1987-2014 and evaluated the incidence of bowel resection after first ever dispensation of adalimumab or infliximab from 2006 and up to 7 years follow-up.Results: We identified 1856 Crohn's disease patients who had received TNFi. Among these patients, 90% treatment retention was observed at 6 months after start of TNFi and 65% remained on the drug after 12 months. The cumulative rates of surgery in Crohn's disease patients exposed to TNFi years 1-7 were 7%, 13%, 17%, 20%, 23%, 25% and 28%. Rates of bowel resection were similar between patients with TNFi survival < 12 months and >= 12 months respectively (P=.27). No predictors (eg, sex, age, extension or duration of disease) for bowel resection were identified.Conclusions: The risk of bowel resection after start of anti-TNF treatment is higher in regular health care than in published RCTs. Patients on sustained TNFi treatment beyond 12 months have bowel resection rates similar to those who discontinue TNFi treatment earlier.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Söderling, J. K.Karolinska Institutet (författare)
  • Neovius, M.Karolinska Institutet (författare)
  • Cars, ThomasUppsala universitet,Kardiovaskulär epidemiologi,Publ Healthcare Serv, Stockholm, Sweden,Public Healthcare Serv, Sweden; Uppsala University, Sweden(Swepub:uu)thomcars (författare)
  • Myrelid, PärLinköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)parmy24 (författare)
  • Ludvigsson, Jonas F.,1969-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Stockholm, Sweden.;Orebro Univ Hosp, Orebro, Sweden.,Karolinska Institute, Sweden; Örebro University Hospital, Sweden(Swepub:oru)jsln (författare)
  • Askling, J.Karolinska Institutet (författare)
  • Ekbom, A.Karolinska Institutet (författare)
  • Olén, O.Karolinska Institutet (författare)
  • Karolinska InstitutetKardiovaskulär epidemiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Alimentary Pharmacology and Therapeutics: John Wiley & Sons46:6, s. 589-5980269-28131365-2036

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