Search: WFRF:(Gulacsi L) >
Cost-utility of bio...
Cost-utility of biological treatment sequences for luminal Crohn's disease in Europe
-
- Rencz, Fanni (author)
- Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary
-
- Gulácsi, László (author)
- Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary
-
- Péntek, Márta (author)
- Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary
-
show more...
-
- Gecse, Krisztina B. (author)
- 1st Department of Medicine, Semmelweis University, Budapest, Hungary
-
- Dignass, Axel (author)
- Department of Medicine 1, Agaplesion Markus Krankenhaus, Frankfurt, Germany
-
- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
-
- Gomollón, Fernando (author)
- Gastroenterology Unit, Clinical Universitary Hospital Lozano IIS Aragón (Blesa, IIS Aragón, CIBEREHD), Zaragoza, Spain
-
- Baji, Petra (author)
- Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary; Center for Economic Research and Graduate Education (CERGE) Economics Institute (EI) Research Fellow, Charles University, Praha, The Czech Republic
-
- Peyrin-Biroulet, Laurent (author)
- Inserm U954 and Department of Hepato-Gastroenterology, University Hospital of Nancy-Brabois, Lorraine University, Vandoeuvre-lès-Nancy, France
-
- Lakatos, Peter L. (author)
- 1st Department of Medicine, Semmelweis University, Budapest, Hungary
-
- Brodszky, Valentin (author)
- Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary
-
show less...
-
(creator_code:org_t)
- 2017-04-28
- 2017
- English.
-
In: Expert review of pharmacoeconomics & outcomes research. - : Taylor & Francis. - 1473-7167 .- 1744-8379. ; 17:6, s. 597-606
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: This study aims to compare the cost-effectiveness of treatment sequences with available biologics, including adalimumab (ADA), biosimilar infliximab (bsIFX), originator infliximab (IFX) and vedolizumab (VEDO) for luminal Crohn's disease in nine European countries.METHODS: A Markov-model was constructed to simulate five-year medical costs and quality-adjusted life years (QALYs). Data on clinical efficacy were obtained from randomised controlled trials. Country-specific unit costs, discount rates and a third-party payer perspective were applied.RESULTS: The bsIFX versus conventional therapy resulted in the most favourable incremental cost-utility ratios (ICURs) ranging from €34,580 (Hungary) to €77,062/QALY (Sweden). Compared to bsIFX, the bsIFX-ADA sequence was more cost-effective than the bsIFX-VEDO sequence with ICURs varying between €70,277 (France) and €162,069/QALY (Germany). The ICURs of the bsIFX-ADA-VEDO sequence versus the bsIFX-ADA strategy were between €206,266 (The Netherlands) and €363,232/QALY (Spain).CONCLUSION: We are the first to compare cost-effectiveness of multiple biological sequences for luminal Crohn's disease. Based on our findings, bsIFX can be recommended as a first-line treatment in patients unresponsive to conventional treatments. While biological sequences only slightly differ in their associated health gains, their costs vary greatly. The bsIFX-ADA-VEDO seems to be the most cost-effective sequence of the available biologics across Europe.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
Keyword
- Adalimumab
- biosimilar infliximab
- cost-effectiveness
- Crohn's disease
- inflammatory bowel diseases; infliximab
- vedolizumab
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Rencz, Fanni
-
Gulácsi, László
-
Péntek, Márta
-
Gecse, Krisztina ...
-
Dignass, Axel
-
Halfvarson, Jona ...
-
show more...
-
Gomollón, Fernan ...
-
Baji, Petra
-
Peyrin-Biroulet, ...
-
Lakatos, Peter L ...
-
Brodszky, Valent ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Health Care Serv ...
- Articles in the publication
-
Expert review of ...
- By the university
-
Örebro University