Sökning: WFRF:(Linder D.) >
Bivalirudin versus ...
Bivalirudin versus Heparin Monotherapy in Myocardial Infarction
-
- Erlinge, D. (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Lund University, Sweden
-
- Omerovic, Elmir (författare)
- Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.
-
- Fröbert, Ole, 1964- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden,Rebro Univ, Fac Hlth, Dept Cardiol, Orebro, Sweden.
-
visa fler...
-
- Linder, Rikard (författare)
- Karolinska Institutet,Danderyd Hospital, Sweden
-
- Danielewicz, Mikael (författare)
- PCI-Unit at Karlstad Hospital, Karlstad, Sweden,Karlstad Hosp, PCI Unit, Karlstad, Sweden.
-
- Hamid, Mehmet (författare)
- Department of Cardiology, Mälarsjukhuset, Eskilstuna, Sweden,Malarsjukhuset, Dept Cardiol, Eskilstuna, Sweden.
-
- Swahn, Eva (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
-
- Henareh, Loghman (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden
-
- Wagner, H. (författare)
- Department of Cardiology, Helsingborg Lasarett, Helsingborg, Sweden,Helsingborg Lasarett, Dept Cardiol, Helsingborg, Sweden.,Helsingborg Hospital
-
- Hårdhammar, Peter (författare)
- Department of Cardiology, Halmstad Hospital, Halmstad, Sweden,Halmstad Cty Hosp, Dept Cardiol, Halmstad, Sweden.,Halmstad County Hospital, Sweden
-
- Sjögren, Iwar (författare)
- Department of Cardiology, Falun Hospital, Falun, Sweden,Falun Cent Hosp, Dept Cardiol, Falun, Sweden.,Falun Central Hospital, Sweden
-
- Stewart, Jason (författare)
- Department of Cardiology, Skaraborgs Hospital, Skövde, Sweden,Skaraborgs Hosp, Dept Cardiol, Skovde, Sweden.
-
- Grimfjärd, Per (författare)
- Department of Internal Medicine, Västmanlands Sjukhus, Västerås, Sweden,Vastmanlands Sjukhus, Dept Internal Med, Vasteras, Sweden.,Västmanland Hospital
-
- Jensen, Jens (författare)
- Umeå University,Karolinska Institute,Karolinska Institutet,Karolinska Institute, Sweden,Sunderby Sjukhus, Sweden,Umeå University, Sweden
-
- Aasa, Mikael (författare)
- Department of Cardiology, Södersjukhuset AB, Stockholm, Sweden,Sodersjukhuset AB, Dept Cardiol, Stockholm, Sweden.,Stockholm South General Hospital
-
- Robertsson, Lotta (författare)
- Department of Internal Medicine, Västmanlands Sjukhus, Västerås, Sweden,Sodra Alvsborgs Sjukhus, Dept Cardiol, Boras, Sweden.,South Elfsborg Hospital
-
- Lindroos, Pontus (författare)
- Department of Cardiology, Capio St. Görans Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Capio St Gorans Hosp, Dept Cardiol, Stockholm, Sweden.,Capio St. Görans Sjukhus
-
- Haupt, Jan (författare)
- Department of Cardiology, Sunderby Sjukhus, Luleå, Sweden,Sunderby Hospital
-
- Wikström, Helena (författare)
- Department of Cardiology, Kristianstad Hospital, Kristianstad, Sweden,Kristianstad Hosp, Dept Cardiol, Kristianstad, Sweden.,Central Hospital Kristianstad
-
- Ulvenstam, Anders (författare)
- Umeå universitet,Avdelningen för medicin,Ostersund Hosp, Dept Cardiol, Ostersund, Sweden.,Östersund Hospital, Sweden
-
- Bhiladvala, P. (författare)
- Lund University,Lunds universitet,Kardiologiska klinikens forskargrupp,Forskargrupper vid Lunds universitet,Cardiology Research Group,Lund University Research Groups,Lund University, Sweden
-
- Lindvall, Bo (författare)
- Department of Cardiology, Sundsvall Hospital, Sundsvall, Sweden,Sundsvall Hosp, Dept Cardiol, Sundsvall, Sweden.
-
- Lundin, Anders (författare)
- Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Dept Cardiol Clin Sci, Lund, Sweden.
-
- Tödt, T. (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden,Sahlgrens University Hospital, Sweden,Örebro University, Sweden
-
- Ioanes, Dan (författare)
- Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.
-
- Råmunddal, Truls (författare)
- Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
-
- Kellerth, Thomas (författare)
- Örebro University
-
- Zagozdzon, Leszek (författare)
- Örebro University,Örebro University, Sweden
-
- Götberg, M. (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
-
- Andersson, Jonas (författare)
- Umeå universitet,Kardiologi
-
- Angerås, Oskar (författare)
- Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.
-
- Östlund, Ollie (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala University, Sweden
-
- Lagerqvist, Bo, 1952- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital,Uppsala University, Sweden
-
- Held, Claes, 1956- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala University Hospital,Uppsala University, Sweden
-
- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital,Uppsala University, Sweden
-
- Scherstén, F. (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
-
- Eriksson, Peter (författare)
- Umeå University,Umeå universitet,Kardiologi,Umea Univ, Dept Cardiol, Umea, Sweden.,Umeå University, Sweden
-
- Koul, S. (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Lund University, Sweden
-
- James, Stefan, 1964- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital,Uppsala University, Sweden
-
- Linder, Robert, 1981- (författare)
- Umeå universitet,Lungmedicin
-
- Abdel-Hamid, Mohamed (författare)
- Mälar Hospital
-
- Östlund, Olof (författare)
- Uppsala University Hospital
-
visa färre...
-
(creator_code:org_t)
- Massachusetts Medical Society, 2017
- 2017
- Engelska.
-
Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 377:12, s. 1132-1142
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://liu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background The comparative efficacy of various anticoagulation strategies has not been clearly established in patients with acute myocardial infarction who are undergoing percutaneous coronary intervention (PCI) according to current practice, which includes the use of radial-artery access for PCI and administration of potent P2Y12 inhibitors without the planned use of glycoprotein IIb/IIIa inhibitors. Methods In this multicenter, randomized, registry-based, open-label clinical trial, we enrolled patients with either ST-segment elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI) who were undergoing PCI and receiving treatment with a potent P2Y12 inhibitor (ticagrelor, prasugrel, or cangrelor) without the planned use of glycoprotein IIb/IIIa inhibitors. The patients were randomly assigned to receive bivalirudin or heparin during PCI, which was performed predominantly with the use of radial-artery access. The primary end point was a composite of death from any cause, myocardial infarction, or major bleeding during 180 days of follow-up. Results A total of 6006 patients (3005 with STEMI and 3001 with NSTEMI) were enrolled in the trial. At 180 days, a primary end-point event had occurred in 12.3% of the patients (369 of 3004) in the bivalirudin group and in 12.8% (383 of 3002) in the heparin group (hazard ratio, 0.96; 95% confidence interval [CI], 0.83 to 1.10; P=0.54). The results were consistent between patients with STEMI and those with NSTEMI and across other major subgroups. Myocardial infarction occurred in 2.0% of the patients in the bivalirudin group and in 2.4% in the heparin group (hazard ratio, 0.84; 95% CI, 0.60 to 1.19; P=0.33), major bleeding in 8.6% and 8.6%, respectively (hazard ratio, 1.00; 95% CI, 0.84 to 1.19; P=0.98), definite stent thrombosis in 0.4% and 0.7%, respectively (hazard ratio, 0.54; 95% CI, 0.27 to 1.10; P=0.09), and death in 2.9% and 2.8%, respectively (hazard ratio, 1.05; 95% CI, 0.78 to 1.41; P=0.76). Conclusions Among patients undergoing PCI for myocardial infarction, the rate of the composite of death from any cause, myocardial infarction, or major bleeding was not lower among those who received bivalirudin than among those who received heparin monotherapy. (Funded by the Swedish Heart-Lung Foundation and others; VALIDATE-SWEDEHEART ClinicalTrialsRegister.eu number, 2012-005260-10 ; ClinicalTrials.gov number, NCT02311231 .).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Erlinge, D.
-
Omerovic, Elmir
-
Fröbert, Ole, 19 ...
-
Linder, Rikard
-
Danielewicz, Mik ...
-
Hamid, Mehmet
-
visa fler...
-
Swahn, Eva
-
Henareh, Loghman
-
Wagner, H.
-
Hårdhammar, Pete ...
-
Sjögren, Iwar
-
Stewart, Jason
-
Grimfjärd, Per
-
Jensen, Jens
-
Aasa, Mikael
-
Robertsson, Lott ...
-
Lindroos, Pontus
-
Haupt, Jan
-
Wikström, Helena
-
Ulvenstam, Ander ...
-
Bhiladvala, P.
-
Lindvall, Bo
-
Lundin, Anders
-
Tödt, T.
-
Ioanes, Dan
-
Råmunddal, Truls
-
Kellerth, Thomas
-
Zagozdzon, Lesze ...
-
Götberg, M.
-
Andersson, Jonas
-
Angerås, Oskar
-
Östlund, Ollie
-
Lagerqvist, Bo, ...
-
Held, Claes, 195 ...
-
Wallentin, Lars, ...
-
Scherstén, F.
-
Eriksson, Peter
-
Koul, S.
-
James, Stefan, 1 ...
-
Linder, Robert, ...
-
Abdel-Hamid, Moh ...
-
Östlund, Olof
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
New England Jour ...
- Av lärosätet
-
Örebro universitet
-
Umeå universitet
-
Uppsala universitet
-
Karolinska Institutet
-
Lunds universitet
-
Linköpings universitet