Sökning: L773:1536 4801 OR L773:0277 2116
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Lack of association...
Lack of association between interleukin 28B polymorphism and vertical transmission of hepatitis C
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- Einberg, Afrodite Psaros (författare)
- Karolinska Institutet
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- Duberg, Ann-Sofi, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Filipovich, Olga (författare)
- North-Western State Medical University of I.I.Mechnikov, Saint Petersburg, Russia
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- Nyström, Jessica (författare)
- Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden
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- Zhirkov, Anton (författare)
- Science Research Institute of Children's Infections, Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia
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- Brenndörfer, Erwin Daniel (författare)
- Karolinska Institutet
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- Frelin, Lars (författare)
- Karolinska Institutet
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- Rukoiatkina, Elena (författare)
- Maternity Hospital No. 16, Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia; Department of Pediatrics, Gynecology and Female Reproductology, Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia
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- Lobzin, Yuriy (författare)
- Science Research Institute of Children's Infections, Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia
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- Sällberg, Matti (författare)
- Karolinska Institutet
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- Fischler, Björn (författare)
- Karolinska Institutet
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- Lutckii, Anton (författare)
- Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden; Science Research Institute of Children's Infections
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2017
- 2017
- Engelska.
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Ingår i: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - : Lippincott Williams & Wilkins. - 0277-2116 .- 1536-4801. ; 65:6, s. 608-612
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: Single genetic nucleotide polymorphism (rs12979860) near the gene for Interleukin 28B (IL28B), is known to be of importance for frequency of spontaneous clearance and treatment outcome in interferon based therapies in patients with hepatitis C virus (HCV) infection. The aim of this study was to investigate if IL28B polymorphism in children and/or their mothers plays a role in vertical transmission of HCV (HCV-VT).METHODS: Plasma samples from 59 infected women, 76 uninfected children born to infected mothers, and 47 children with known vertically transmitted HCV infection, were analysed for IL28B polymorphism and classified by the IL28B genotype (C/C, C/T and T/T) as well as by viral genotype.RESULTS: The proportion of children with genotype C/C was the same in the vertically infected (36%, 17/47) and the exposed uninfected children (38%, 29/76). No difference was seen when stratifying for viral genotype. There was no association between mothers' IL28B genotype and the risk of vertical transmission.CONCLUSION: Regardless of viral genotype we found no association between IL28B genotype and the risk of HCV-VT. The IL28B genotype CC, which has been shown to be favourable in other settings, was not protective of HCV-VT. Thus, other factors possibly associated with the risk of HCV-VT need to be explored.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Hepatitis C
- hepatitis C virus
- interleukin 28B single genetic nucleotide polymorphism
- mother-to-child-transmission
- perinatal transmission
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Till lärosätets databas
- Av författaren/redakt...
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Einberg, Afrodit ...
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Duberg, Ann-Sofi ...
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Filipovich, Olga
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Nyström, Jessica
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Zhirkov, Anton
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Brenndörfer, Erw ...
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Frelin, Lars
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Rukoiatkina, Ele ...
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Lobzin, Yuriy
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Sällberg, Matti
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Fischler, Björn
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Lutckii, Anton
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- Av lärosätet
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Örebro universitet
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Karolinska Institutet