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The expression of v...
The expression of vascular endothelial growth factor in skeletal muscle of patients with sleep disorders
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- Wåhlin-Larsson, Britta, 1959- (author)
- Högskolan Dalarna,Örebro universitet,Hälsoakademin,Dalarna University, Falun, Sweden,Research in musculoskeletal health and disease , RISPA,Medicinsk vetenskap
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- Ulfberg, Jan (author)
- Avesta Hospital, Avesta, Sweden
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- Piehl-Aulin, Karin (author)
- Örebro universitet,Hälsoakademin,Research in musculoskeletal health and disease
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- Kadi, Fawzi, 1970- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,RISPA- MEP-RG
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(creator_code:org_t)
- New York, NY : John Wiley & Sons, 2009
- 2009
- English.
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In: Muscle and Nerve. - New York, NY : John Wiley & Sons. - 0148-639X .- 1097-4598. ; 40:4, s. 556-561
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- An increased capillary network has been observed in the skeletal muscle in patients with Restless Legs Syndrome (RLS) and Obstructive sleep apnea syndrome (OSAS). These changes could be due to upregulation of growth factors responsible for angiogenesis.The aim of the study was to examine the occurrence and localization of VEGF and capillary proliferation in skeletal muscle of RLS (n=12), OSAS (n=12) and controls (n=11).Double-immunofluorescence staining for capillaries (CD31) and VEGF, and proliferating cells (Ki-67), was carried out on biopsies taken from the tibialis anterior. The percentage of capillaries expressing VEGF (CD31,VEGF+) was significantly higher in OSAS and RLS compared to controls. The percentage of proliferating capillaries (CD31,Ki-67+) was significantly higher in OSAS compared with controls.In conclusion our study shows the occurrence of proliferation of endothelial cells in skeletal muscle in RLS and OSAS, supporting an upregulation of VEGF located in capillaries probably due to local hypoxia.
Subject headings
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Tvärvetenskapliga studier inom samhällsvetenskap (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Social Sciences Interdisciplinary (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- VEGF
- immunofluorescence
- capillary
- RLS
- OSAS
- MEDICINE
- MEDICIN
- INTERDISCIPLINARY RESEARCH AREAS
- TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN
- Sports Science
- Idrottsvetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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