RhoB controls the Rab11-mediated recycling and surface reappearance of LFA-1 in migrating T lymphocytes

Samuelsson, MalinLund University,Lunds universitet,Leukocyt migration,Forskargrupper vid Lunds universitet,Leukocyte Migration,Lund University Research Groups (författare)

Washington, DC, USA :American Association for the Advancement of Science (A A A S),2017
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Funding Agencies:Foundation Olle Engquist Byggmästare IngaBritt & Arne Lundberg Research Foundation Royal Physiographic Society of Lund Åke Wiberg Jeanssons Foundation Kocks Foundation Per-Eric and Ulla Schybergs Foundation Gyllenstiernska Krapperup Foundation Gustav V 80 Jubilee Fund Österlund Foundation Nanna Svartz award Crafoord award Anna-Greta Crafoord postdoctoral fellowship
The regulation of cell adhesion and motility is complex and requires the intracellular trafficking of integrins to and from sites of cell adhesion, especially in fast-moving cells such as leukocytes. The Rab family of guanosine triphosphatases (GTPases) is essential for vesicle transport, and vesicles mediate intracellular integrin trafficking. We showed that RhoB regulates the vesicular transport of the integrin LFA-1 along the microtubule network in migrating T lymphocytes. Impairment in RhoB function resulted in the accumulation of both LFA-1 and the recycling endosomal marker Rab11 at the rear of migrating T lymphocytes and decreased the association between these molecules. T lymphocytes lacking functional RhoB exhibited impaired recycling and subsequently decreased surface amounts of LFA-1, leading to reduced T cell adhesion and migration mediated by the cell adhesion molecule ICAM-1 (intercellular adhesion molecule-1). We propose that vesicle-associated RhoB is a regulator of the Rab11-mediated recycling of LFA-1 to the cell surface, an event that is necessary for T lymphocyte motility.

Potrzebowska, KatarzynaLund University,Lunds universitet,Leukocyt migration,Forskargrupper vid Lunds universitet,Leukocyte Migration,Lund University Research Groups(Swepub:lu)med-kpw (författare)
Lehtonen, JanneLund University,Lunds universitet,Leukocyt migration,Forskargrupper vid Lunds universitet,Leukocyte Migration,Lund University Research Groups(Swepub:lu)ja2334le (författare)
Beech, Jason P.Lund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ftf-job (författare)
Skorova, EkatarinaDepartment of Experimental Medical Science, Lund University, Lund, Sweden (författare)
Uronen-Hansson, HeliLund University,Lunds universitet,Leukocyt migration,Forskargrupper vid Lunds universitet,Leukocyte Migration,Lund University Research Groups(Swepub:lu)med-hiu (författare)
Svensson, Lena,1973-Örebro University,Lund University,Lunds universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Experimental Medical Science, Lund University, Lund, Sweden,Leukocyt migration,Forskargrupper vid Lunds universitet,Leukocyte Migration,Lund University Research Groups(Swepub:lu)med-l_s (författare)
Leukocyt migrationForskargrupper vid Lunds universitet (creator_code:org_t)

Ingår i:Science SignalingWashington, DC, USA : American Association for the Advancement of Science (A A A S)10:5091945-08771937-9145

Av författaren/redakt...: Samuelsson, Mali ...; Potrzebowska, Ka ...; Lehtonen, Janne; Beech, Jason P.; Skorova, Ekatari ...; Uronen-Hansson, ...; visa fler...; Svensson, Lena, ...; visa färre...

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