Sökning: WFRF:(Westerbacka Jukka) >
Comparison of lipid...
Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum
-
- Kotronen, Anna (författare)
- Department of Medicine, Division of Diabetes, , Helsinki, Finland; Minerva Medical Research Institute, Helsinki, Finland
-
- Seppänen-Laakso, Tuulikki (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
-
- Westerbacka, Jukka (författare)
- Department of Medicine, Division of Diabetes, , Helsinki, Finland
-
visa fler...
-
- Kiviluoto, Tuula (författare)
- Department of Surgery, University of Helsinki, Helsinki, Finland
-
- Arola, Johanna (författare)
- Department of Pathology, HUSLAB, University of Helsinki, Helsinki, Finland
-
- Ruskeepää, Anna-Liisa (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
-
- Yki-Järvinen, Hannele (författare)
- Department of Medicine, Division of Diabetes, , Helsinki, Finland
-
- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
-
visa färre...
-
(creator_code:org_t)
- 2012-09-06
- 2010
- Engelska.
-
Ingår i: Obesity. - : Wiley-Blackwell Publishing Inc.. - 1930-7381 .- 1930-739X. ; 18:5, s. 937-944
- Relaterad länk:
-
https://onlinelibrar...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Ceramides may mediate saturated fat-induced insulin resistance, but there are no data comparing ceramide concentrations between human tissues. We therefore performed lipidomic analysis of human subcutaneous (SCfat) and intra-abdominal (IAfat) adipose tissue, the liver, and serum in eight subjects. The liver contained (nmol/mg tissue) significantly more ceramides (1.5-3-fold), sphingomyelins (7-8-fold), phosphatidylethanolamines (10-11-fold), lysophosphatidylcholines (7-12-fold), less ether-linked phosphatidylcholines (2-2.5-fold) but similar amounts of diacylglycerols as compared to SCfat and IAfat. The amounts of ceramides and their synthetic precursors, such as palmitic (16:0) free fatty acids and sphingomyelins, differed considerably between the tissues. The liver contained proportionally more palmitic, stearic (18:0), and long polyunsaturated fatty acids than adipose tissues. Stearoyl-CoA desaturase 1 (SCD1) activity reflected by serum, estimated from the 16:1/16:0-ratio, was closely related to that in the liver (r = 0.86, P = 0.024) but not adipose tissues. This was also true for estimated elongase (18:1/16:1, r = 0.89, P = 0.01), and Delta5 (20:4/20:3, r = 0.89, P = 0.012) and Delta6 (18:3[n-6]/18:2, r = 1.0, P < 0.001) desaturase activities. We conclude that the human liver contains higher concentrations of ceramides and saturated free fatty acids than either SCfat or IAfat.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Obesity
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas