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Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming

Elo, Laura L. (author)
Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
Järvenpää, Henna (author)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
Tuomela, Soile (author)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
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Raghav, Sunil (author)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
Ahlfors, Helena (author)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; The National Graduate School in Informational and Structural Biology, Åbo Akademi University, Turku, Finland
Laurila, Kirsti (author)
Department of Signal Processing, Tampere University of Technology, Tampere, Finland
Gupta, Bhawna (author)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
Lund, Riikka J. (author)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Department of Biological Science, University of Sheffield, Sheffield, United Kingdom
Tahvanainen, Johanna (author)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Drug Discovery Graduate School, University of Turku, Turku, Finland
Hawkins, R. David (author)
Ludwig Institute for Cancer Research, University of California, San Diego CA, United States
Oresic, Matej, 1967- (author)
VTT Technical Research Centre of Finland, Espoo, Finland
Lähdesmäki, Harri (author)
Department of Signal Processing, Tampere University of Technology, Tampere, Finland; Department of Information and Computer Science, Helsinki University of Technology, Helsinki, Finland
Rasool, Omid (author)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
Rao, Kanury V. (author)
Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland
Aittokallio, Tero (author)
International Centre for Genetic Engineering and Biotechnology, New Delhi, India; Immune Disease Institute, Harvard Medical School, Boston MA, United States
Lahesmaa, Riitta (author)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Immune Disease Institute, Harvard Medical School, Boston MA, United States
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 (creator_code:org_t)
Cell Press, 2010
2010
English.
In: Immunity. - : Cell Press. - 1074-7613 .- 1097-4180. ; 32:6, s. 852-862
Related links:
https://doi.org/10.1...
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http://www.cell.com/...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
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  • Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.

Subject headings

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)

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