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Genome-wide profili...
Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming
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- Elo, Laura L. (author)
- Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
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- Järvenpää, Henna (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
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- Tuomela, Soile (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
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- Raghav, Sunil (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
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- Ahlfors, Helena (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; The National Graduate School in Informational and Structural Biology, Åbo Akademi University, Turku, Finland
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- Laurila, Kirsti (author)
- Department of Signal Processing, Tampere University of Technology, Tampere, Finland
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- Gupta, Bhawna (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
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- Lund, Riikka J. (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Department of Biological Science, University of Sheffield, Sheffield, United Kingdom
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- Tahvanainen, Johanna (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Drug Discovery Graduate School, University of Turku, Turku, Finland
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- Hawkins, R. David (author)
- Ludwig Institute for Cancer Research, University of California, San Diego CA, United States
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- Oresic, Matej, 1967- (author)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Lähdesmäki, Harri (author)
- Department of Signal Processing, Tampere University of Technology, Tampere, Finland; Department of Information and Computer Science, Helsinki University of Technology, Helsinki, Finland
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- Rasool, Omid (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
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- Rao, Kanury V. (author)
- Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland
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- Aittokallio, Tero (author)
- International Centre for Genetic Engineering and Biotechnology, New Delhi, India; Immune Disease Institute, Harvard Medical School, Boston MA, United States
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- Lahesmaa, Riitta (author)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Immune Disease Institute, Harvard Medical School, Boston MA, United States
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(creator_code:org_t)
- Cell Press, 2010
- 2010
- English.
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In: Immunity. - : Cell Press. - 1074-7613 .- 1097-4180. ; 32:6, s. 852-862
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Abstract
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- Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Immunity
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- By the author/editor
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Elo, Laura L.
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Järvenpää, Henna
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Tuomela, Soile
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Raghav, Sunil
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Ahlfors, Helena
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Laurila, Kirsti
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show more...
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Gupta, Bhawna
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Lund, Riikka J.
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Tahvanainen, Joh ...
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Hawkins, R. Davi ...
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Oresic, Matej, 1 ...
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Lähdesmäki, Harr ...
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Rasool, Omid
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Rao, Kanury V.
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Aittokallio, Ter ...
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Lahesmaa, Riitta
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Immunity
- By the university
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Örebro University