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Hypothalamic AMPK a...
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
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- López, Miguel (författare)
- Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain; Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
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- Varela, Luis (författare)
- Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain
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- Vázquez, María J (författare)
- Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain
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- Rodríguez-Cuenca, Sergio (författare)
- Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
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- González, Carmen R. (författare)
- Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain
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- Velagapudi, Vidya R. (författare)
- Technical Research Centre of Finland (VTT), Espoo, Finland
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- Morgan, Donald A. (författare)
- Department of Internal Medicine, University of Iowa Carver, College of Medicine, Iowa City IA, United States
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- Schoenmakers, Erik (författare)
- Department of Internal Medicine, University of Iowa Carver, College of Medicine, Iowa City IA, United States
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- Agassandian, Khristofor (författare)
- Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City IA, United States
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- Lage, Ricardo (författare)
- Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain
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- Martínez de Morentin, Pablo Blanco (författare)
- Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain
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- Tovar, Sulay (författare)
- Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain
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- Nogueiras, Rubén (författare)
- Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain
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- Carling, David (författare)
- Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Imperial College, London, United Kingdom
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- Lelliott, Christopher (författare)
- Department of Biosciences, AstraZeneca Research and Development, Mölndal, Sweden
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- Gallego, Rosalía (författare)
- Department of Morphological Sciences, School of Medicine, University of Santiago de Compostela, A Coruña, Spain
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Technical Research Centre of Finland (VTT), Espoo, Finland
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- Chatterjee, Krishna (författare)
- Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
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- Saha, Asish K (författare)
- Diabetes Research Unit, Boston Medical Center, Boston MA, United States
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- Rahmouni, Kamal (författare)
- Department of Internal Medicine, University of Iowa Carver, College of Medicine, Iowa City IA, United States
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- Diéguez, Carlos (författare)
- Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain
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- Vidal-Puig, Antonio (författare)
- Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
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(creator_code:org_t)
- 2010-08-29
- 2010
- Engelska.
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Ingår i: Nature Medicine. - : Nature Publishing Group. - 1078-8956 .- 1546-170X. ; 16:9, s. 1001-1008
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Thyroid hormones have widespread cellular effects; however it is unclear whether their effects on the central nervous system (CNS) contribute to global energy balance. Here we demonstrate that either whole-body hyperthyroidism or central administration of triiodothyronine (T3) decreases the activity of hypothalamic AMP-activated protein kinase (AMPK), increases sympathetic nervous system (SNS) activity and upregulates thermogenic markers in brown adipose tissue (BAT). Inhibition of the lipogenic pathway in the ventromedial nucleus of the hypothalamus (VMH) prevents CNS-mediated activation of BAT by thyroid hormone and reverses the weight loss associated with hyperthyroidism. Similarly, inhibition of thyroid hormone receptors in the VMH reverses the weight loss associated with hyperthyroidism. This regulatory mechanism depends on AMPK inactivation, as genetic inhibition of this enzyme in the VMH of euthyroid rats induces feeding-independent weight loss and increases expression of thermogenic markers in BAT. These effects are reversed by pharmacological blockade of the SNS. Thus, thyroid hormone-induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
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López, Miguel
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Varela, Luis
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Vázquez, María J
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Rodríguez-Cuenca ...
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González, Carmen ...
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Velagapudi, Vidy ...
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Morgan, Donald A ...
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Schoenmakers, Er ...
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Agassandian, Khr ...
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Lage, Ricardo
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Martínez de More ...
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Tovar, Sulay
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Nogueiras, Rubén
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Carling, David
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Lelliott, Christ ...
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Gallego, Rosalía
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Oresic, Matej, 1 ...
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Chatterjee, Kris ...
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Saha, Asish K
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Rahmouni, Kamal
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Diéguez, Carlos
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Vidal-Puig, Anto ...
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