SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Lage K.)
 

Sökning: WFRF:(Lage K.) > Hypothalamic AMPK a...

  • López, MiguelDepartment of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain; Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom (författare)

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • 2010-08-29
  • Nature Publishing Group,2010
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-63637
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63637URI
  • https://doi.org/10.1038/nm.2207DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:UK Medical Research Council G0802051
  • Thyroid hormones have widespread cellular effects; however it is unclear whether their effects on the central nervous system (CNS) contribute to global energy balance. Here we demonstrate that either whole-body hyperthyroidism or central administration of triiodothyronine (T3) decreases the activity of hypothalamic AMP-activated protein kinase (AMPK), increases sympathetic nervous system (SNS) activity and upregulates thermogenic markers in brown adipose tissue (BAT). Inhibition of the lipogenic pathway in the ventromedial nucleus of the hypothalamus (VMH) prevents CNS-mediated activation of BAT by thyroid hormone and reverses the weight loss associated with hyperthyroidism. Similarly, inhibition of thyroid hormone receptors in the VMH reverses the weight loss associated with hyperthyroidism. This regulatory mechanism depends on AMPK inactivation, as genetic inhibition of this enzyme in the VMH of euthyroid rats induces feeding-independent weight loss and increases expression of thermogenic markers in BAT. These effects are reversed by pharmacological blockade of the SNS. Thus, thyroid hormone-induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Varela, LuisDepartment of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain (författare)
  • Vázquez, María JDepartment of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain (författare)
  • Rodríguez-Cuenca, SergioInstitute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom (författare)
  • González, Carmen R.Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain (författare)
  • Velagapudi, Vidya R.Technical Research Centre of Finland (VTT), Espoo, Finland (författare)
  • Morgan, Donald A.Department of Internal Medicine, University of Iowa Carver, College of Medicine, Iowa City IA, United States (författare)
  • Schoenmakers, ErikDepartment of Internal Medicine, University of Iowa Carver, College of Medicine, Iowa City IA, United States (författare)
  • Agassandian, KhristoforDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City IA, United States (författare)
  • Lage, RicardoDepartment of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain (författare)
  • Martínez de Morentin, Pablo BlancoDepartment of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain (författare)
  • Tovar, SulayDepartment of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain (författare)
  • Nogueiras, RubénDepartment of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain (författare)
  • Carling, DavidMedical Research Council Clinical Sciences Centre, Hammersmith Hospital, Imperial College, London, United Kingdom (författare)
  • Lelliott, ChristopherDepartment of Biosciences, AstraZeneca Research and Development, Mölndal, Sweden (författare)
  • Gallego, RosalíaDepartment of Morphological Sciences, School of Medicine, University of Santiago de Compostela, A Coruña, Spain (författare)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Technical Research Centre of Finland (VTT), Espoo, Finland(Swepub:oru)moc (författare)
  • Chatterjee, KrishnaInstitute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom (författare)
  • Saha, Asish KDiabetes Research Unit, Boston Medical Center, Boston MA, United States (författare)
  • Rahmouni, KamalDepartment of Internal Medicine, University of Iowa Carver, College of Medicine, Iowa City IA, United States (författare)
  • Diéguez, CarlosDepartment of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain (författare)
  • Vidal-Puig, AntonioInstitute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom (författare)
  • Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain; Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United KingdomDepartment of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela A Coruña, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion, A Coruña, Spain (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Medicine: Nature Publishing Group16:9, s. 1001-10081078-89561546-170X

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy