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  • Prawitt, JanneUniversity of Lille Nord de France, Lille, France; Institut national de la santé et de la recherche médicale (INSERM), unité mixte de recherche (UMR)1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)

Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • 2011-06-20
  • American Diabetes Association,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-63648
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63648URI
  • https://doi.org/10.2337/db11-0030DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:European Union 018734 Agence Nationale de la Recherche A05056GS COST Action BM0602 
  • OBJECTIVE: Bile acids (BA) participate in the maintenance of metabolic homeostasis acting through different signaling pathways. The nuclear BA receptor farnesoid X receptor (FXR) regulates pathways in BA, lipid, glucose, and energy metabolism, which become dysregulated in obesity. However, the role of FXR in obesity and associated complications, such as dyslipidemia and insulin resistance, has not been directly assessed.RESEARCH DESIGN AND METHODS: Here, we evaluate the consequences of FXR deficiency on body weight development, lipid metabolism, and insulin resistance in murine models of genetic and diet-induced obesity.RESULTS: FXR deficiency attenuated body weight gain and reduced adipose tissue mass in both models. Surprisingly, glucose homeostasis improved as a result of an enhanced glucose clearance and adipose tissue insulin sensitivity. In contrast, hepatic insulin sensitivity did not change, and liver steatosis aggravated as a result of the repression of β-oxidation genes. In agreement, liver-specific FXR deficiency did not protect from diet-induced obesity and insulin resistance, indicating a role for nonhepatic FXR in the control of glucose homeostasis in obesity. Decreasing elevated plasma BA concentrations in obese FXR-deficient mice by administration of the BA sequestrant colesevelam improved glucose homeostasis in a FXR-dependent manner, indicating that the observed improvements by FXR deficiency are not a result of indirect effects of altered BA metabolism.CONCLUSIONS: Overall, FXR deficiency in obesity beneficially affects body weight development and glucose homeostasis.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Abdelkarim, MouaadhUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • Stroeve, Johanna H. M.Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Medical Center Groningen, Groningen, Netherlands (författare)
  • Popescu, IulianaUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • Duez, HeleneUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • Velagapudi, Vidya R (författare)
  • Dumont, JulieUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • Bouchaert, EmmanuelUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • van Dijk, Theo H.Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Medical Center Groningen, Groningen, Netherlands (författare)
  • Lucas, AnthonyUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • Dorchies, EmilieUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • Daoudi, MehdiUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • Lestavel, SophieUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • Gonzalez, Frank JLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda MD, United States (författare)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc (författare)
  • Cariou, BertrandUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France; NSERM U915, Nantes, France; Faculty of Medicine, University of Nantes, Thorax Institute, Nantes, France; Clinic of Endocrinology, University Hospital Center Nantes, Nantes, France (författare)
  • Kuipers, FolkertCenter for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Medical Center Groningen, Groningen, Netherlands (författare)
  • Caron, SandrineUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • Staels, BartUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (författare)
  • University of Lille Nord de France, Lille, France; Institut national de la santé et de la recherche médicale (INSERM), unité mixte de recherche (UMR)1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, FranceUniversity of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes: American Diabetes Association60:7, s. 1861-18710012-17971939-327X

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  • Diabetes (Sök värdpublikationen i LIBRIS)

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