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Sökning: WFRF:(Velagapudi Vidya R) > Farnesoid X recepto...

Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity

Prawitt, Janne (författare)
University of Lille Nord de France, Lille, France; Institut national de la santé et de la recherche médicale (INSERM), unité mixte de recherche (UMR)1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
Abdelkarim, Mouaadh (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
Stroeve, Johanna H. M. (författare)
Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Medical Center Groningen, Groningen, Netherlands
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Popescu, Iuliana (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
Duez, Helene (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
Velagapudi, Vidya R (författare)
Dumont, Julie (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
Bouchaert, Emmanuel (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
van Dijk, Theo H. (författare)
Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Medical Center Groningen, Groningen, Netherlands
Lucas, Anthony (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
Dorchies, Emilie (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
Daoudi, Mehdi (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
Lestavel, Sophie (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
Gonzalez, Frank J (författare)
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda MD, United States
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
Cariou, Bertrand (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France; NSERM U915, Nantes, France; Faculty of Medicine, University of Nantes, Thorax Institute, Nantes, France; Clinic of Endocrinology, University Hospital Center Nantes, Nantes, France
Kuipers, Folkert (författare)
Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Medical Center Groningen, Groningen, Netherlands
Caron, Sandrine (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
Staels, Bart (författare)
University of Lille Nord de France, Lille, France; INSERM UMR1011, Lille, France; UDSL, Lille, France; Institut Pasteur de Lille, Lille, France
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 (creator_code:org_t)
2011-06-20
2011
Engelska.
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 60:7, s. 1861-1871
Relaterad länk:
https://doi.org/10.2...
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http://diabetes.diab...
https://urn.kb.se/re...
https://doi.org/10.2...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVE: Bile acids (BA) participate in the maintenance of metabolic homeostasis acting through different signaling pathways. The nuclear BA receptor farnesoid X receptor (FXR) regulates pathways in BA, lipid, glucose, and energy metabolism, which become dysregulated in obesity. However, the role of FXR in obesity and associated complications, such as dyslipidemia and insulin resistance, has not been directly assessed.RESEARCH DESIGN AND METHODS: Here, we evaluate the consequences of FXR deficiency on body weight development, lipid metabolism, and insulin resistance in murine models of genetic and diet-induced obesity.RESULTS: FXR deficiency attenuated body weight gain and reduced adipose tissue mass in both models. Surprisingly, glucose homeostasis improved as a result of an enhanced glucose clearance and adipose tissue insulin sensitivity. In contrast, hepatic insulin sensitivity did not change, and liver steatosis aggravated as a result of the repression of β-oxidation genes. In agreement, liver-specific FXR deficiency did not protect from diet-induced obesity and insulin resistance, indicating a role for nonhepatic FXR in the control of glucose homeostasis in obesity. Decreasing elevated plasma BA concentrations in obese FXR-deficient mice by administration of the BA sequestrant colesevelam improved glucose homeostasis in a FXR-dependent manner, indicating that the observed improvements by FXR deficiency are not a result of indirect effects of altered BA metabolism.CONCLUSIONS: Overall, FXR deficiency in obesity beneficially affects body weight development and glucose homeostasis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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