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  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland (author)

Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-08-15
  • American Diabetes Association,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-63682
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63682URI
  • https://doi.org/10.2337/db13-0159DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research) 250114 Juvenile Diabetes Research Foundation 36-2008-919 
  • Previous studies show that children who later progress to type 1 diabetes (T1D) have decreased preautoimmune concentrations of multiple phospholipids as compared with nonprogressors. It is still unclear whether these changes associate with development of β-cell autoimmunity or specifically with clinical T1D. Here, we studied umbilical cord serum lipidome in infants who later developed T1D (N = 33); infants who developed three or four (N = 31) islet autoantibodies, two (N = 31) islet autoantibodies, or one (N = 48) islet autoantibody during the follow-up; and controls (N = 143) matched for sex, HLA-DQB1 genotype, city of birth, and period of birth. The analyses of serum molecular lipids were performed using the established lipidomics platform based on ultra-performance liquid chromatography coupled to mass spectrometry. We found that T1D progressors are characterized by a distinct cord blood lipidomic profile that includes reduced major choline-containing phospholipids, including sphingomyelins and phosphatidylcholines. A molecular signature was developed comprising seven lipids that predicted high risk for progression to T1D with an odds ratio of 5.94 (95% CI, 1.07-17.50). Reduction in choline-containing phospholipids in cord blood therefore is specifically associated with progression to T1D but not with development of β-cell autoimmunity in general.

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  • Gopalacharyulu, PeddintiVTT Technical Research Centre of Finland, Espoo, Finland (author)
  • Mykkänen, JuhaDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland (author)
  • Lietzen, NiinaVTT Technical Research Centre of Finland, Espoo, Finland (author)
  • Mäkinen, MarjaanaDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland (author)
  • Nygren, HeliVTT Technical Research Centre of Finland, Espoo, Finland (author)
  • Simell, SatuDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland (author)
  • Simell, VilleDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland (author)
  • Hyöty, HeikkiDepartment of Virology, School of Medicine, University of Tampere, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland (author)
  • Veijola, RiittaInstitute of Clinical Medicine, University of Oulu, Oulu, Finland (author)
  • Ilonen, JormaDepartment of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland; Immunogenetics Laboratory, University of Turku, Turku, Finland (author)
  • Sysi-Aho, MarkoVTT Technical Research Centre of Finland, Espoo, Finland (author)
  • Knip, MikaelChildren’s Hospital, University of Helsinki, Helsinki, Finland; Helsinki University Central Hospital, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Folkhälsan Research Center, Helsinki, Finland (author)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)tihn (author)
  • Simell, OlliDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland (author)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Diabetes: American Diabetes Association62:9, s. 3268-32740012-17971939-327X

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