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Cord serum lipidome...
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Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
(author)
Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-08-15
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American Diabetes Association,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-63682
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63682URI
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https://doi.org/10.2337/db13-0159DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding agencies:Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research) 250114 Juvenile Diabetes Research Foundation 36-2008-919
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Previous studies show that children who later progress to type 1 diabetes (T1D) have decreased preautoimmune concentrations of multiple phospholipids as compared with nonprogressors. It is still unclear whether these changes associate with development of β-cell autoimmunity or specifically with clinical T1D. Here, we studied umbilical cord serum lipidome in infants who later developed T1D (N = 33); infants who developed three or four (N = 31) islet autoantibodies, two (N = 31) islet autoantibodies, or one (N = 48) islet autoantibody during the follow-up; and controls (N = 143) matched for sex, HLA-DQB1 genotype, city of birth, and period of birth. The analyses of serum molecular lipids were performed using the established lipidomics platform based on ultra-performance liquid chromatography coupled to mass spectrometry. We found that T1D progressors are characterized by a distinct cord blood lipidomic profile that includes reduced major choline-containing phospholipids, including sphingomyelins and phosphatidylcholines. A molecular signature was developed comprising seven lipids that predicted high risk for progression to T1D with an odds ratio of 5.94 (95% CI, 1.07-17.50). Reduction in choline-containing phospholipids in cord blood therefore is specifically associated with progression to T1D but not with development of β-cell autoimmunity in general.
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Gopalacharyulu, PeddintiVTT Technical Research Centre of Finland, Espoo, Finland
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Mykkänen, JuhaDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland
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Lietzen, NiinaVTT Technical Research Centre of Finland, Espoo, Finland
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Mäkinen, MarjaanaDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland
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Nygren, HeliVTT Technical Research Centre of Finland, Espoo, Finland
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Simell, SatuDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland
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Simell, VilleDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland
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Hyöty, HeikkiDepartment of Virology, School of Medicine, University of Tampere, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
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Veijola, RiittaInstitute of Clinical Medicine, University of Oulu, Oulu, Finland
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Ilonen, JormaDepartment of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland; Immunogenetics Laboratory, University of Turku, Turku, Finland
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Sysi-Aho, MarkoVTT Technical Research Centre of Finland, Espoo, Finland
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Knip, MikaelChildren’s Hospital, University of Helsinki, Helsinki, Finland; Helsinki University Central Hospital, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Folkhälsan Research Center, Helsinki, Finland
(author)
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Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)tihn
(author)
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Simell, OlliDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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In:Diabetes: American Diabetes Association62:9, s. 3268-32740012-17971939-327X
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