SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Veijola Juha)
 

Sökning: WFRF:(Veijola Juha) > Cord serum lipidome...

  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland (författare)

Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • 2013-08-15
  • American Diabetes Association,2013
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-63682
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63682URI
  • https://doi.org/10.2337/db13-0159DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research) 250114 Juvenile Diabetes Research Foundation 36-2008-919 
  • Previous studies show that children who later progress to type 1 diabetes (T1D) have decreased preautoimmune concentrations of multiple phospholipids as compared with nonprogressors. It is still unclear whether these changes associate with development of β-cell autoimmunity or specifically with clinical T1D. Here, we studied umbilical cord serum lipidome in infants who later developed T1D (N = 33); infants who developed three or four (N = 31) islet autoantibodies, two (N = 31) islet autoantibodies, or one (N = 48) islet autoantibody during the follow-up; and controls (N = 143) matched for sex, HLA-DQB1 genotype, city of birth, and period of birth. The analyses of serum molecular lipids were performed using the established lipidomics platform based on ultra-performance liquid chromatography coupled to mass spectrometry. We found that T1D progressors are characterized by a distinct cord blood lipidomic profile that includes reduced major choline-containing phospholipids, including sphingomyelins and phosphatidylcholines. A molecular signature was developed comprising seven lipids that predicted high risk for progression to T1D with an odds ratio of 5.94 (95% CI, 1.07-17.50). Reduction in choline-containing phospholipids in cord blood therefore is specifically associated with progression to T1D but not with development of β-cell autoimmunity in general.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gopalacharyulu, PeddintiVTT Technical Research Centre of Finland, Espoo, Finland (författare)
  • Mykkänen, JuhaDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland (författare)
  • Lietzen, NiinaVTT Technical Research Centre of Finland, Espoo, Finland (författare)
  • Mäkinen, MarjaanaDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland (författare)
  • Nygren, HeliVTT Technical Research Centre of Finland, Espoo, Finland (författare)
  • Simell, SatuDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland (författare)
  • Simell, VilleDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland (författare)
  • Hyöty, HeikkiDepartment of Virology, School of Medicine, University of Tampere, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland (författare)
  • Veijola, RiittaInstitute of Clinical Medicine, University of Oulu, Oulu, Finland (författare)
  • Ilonen, JormaDepartment of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland; Immunogenetics Laboratory, University of Turku, Turku, Finland (författare)
  • Sysi-Aho, MarkoVTT Technical Research Centre of Finland, Espoo, Finland (författare)
  • Knip, MikaelChildren’s Hospital, University of Helsinki, Helsinki, Finland; Helsinki University Central Hospital, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Folkhälsan Research Center, Helsinki, Finland (författare)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)tihn (författare)
  • Simell, OlliDepartment of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland (författare)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes: American Diabetes Association62:9, s. 3268-32740012-17971939-327X

Internetlänk

Hitta via bibliotek

  • Diabetes (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy