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Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes

Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
Gopalacharyulu, Peddinti (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Mykkänen, Juha (författare)
Department of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland
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Lietzen, Niina (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Mäkinen, Marjaana (författare)
Department of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland
Nygren, Heli (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Simell, Satu (författare)
Department of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland
Simell, Ville (författare)
Department of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland
Hyöty, Heikki (författare)
Department of Virology, School of Medicine, University of Tampere, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
Veijola, Riitta (författare)
Institute of Clinical Medicine, University of Oulu, Oulu, Finland
Ilonen, Jorma (författare)
Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland; Immunogenetics Laboratory, University of Turku, Turku, Finland
Sysi-Aho, Marko (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Knip, Mikael (författare)
Children’s Hospital, University of Helsinki, Helsinki, Finland; Helsinki University Central Hospital, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Folkhälsan Research Center, Helsinki, Finland
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland
Simell, Olli (författare)
Department of Pediatrics, University of Turku, Turku, Finland; Hospital District of Southwest Finland, Turku, Finland
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 (creator_code:org_t)
2013-08-15
2013
Engelska.
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 62:9, s. 3268-3274
Relaterad länk:
https://doi.org/10.2...
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https://diabetes.dia...
https://urn.kb.se/re...
https://doi.org/10.2...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Previous studies show that children who later progress to type 1 diabetes (T1D) have decreased preautoimmune concentrations of multiple phospholipids as compared with nonprogressors. It is still unclear whether these changes associate with development of β-cell autoimmunity or specifically with clinical T1D. Here, we studied umbilical cord serum lipidome in infants who later developed T1D (N = 33); infants who developed three or four (N = 31) islet autoantibodies, two (N = 31) islet autoantibodies, or one (N = 48) islet autoantibody during the follow-up; and controls (N = 143) matched for sex, HLA-DQB1 genotype, city of birth, and period of birth. The analyses of serum molecular lipids were performed using the established lipidomics platform based on ultra-performance liquid chromatography coupled to mass spectrometry. We found that T1D progressors are characterized by a distinct cord blood lipidomic profile that includes reduced major choline-containing phospholipids, including sphingomyelins and phosphatidylcholines. A molecular signature was developed comprising seven lipids that predicted high risk for progression to T1D with an odds ratio of 5.94 (95% CI, 1.07-17.50). Reduction in choline-containing phospholipids in cord blood therefore is specifically associated with progression to T1D but not with development of β-cell autoimmunity in general.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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