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  • Bondia-Pons, IsabelVTT Technical Research Centre of Finland, Espoo, Finland; Department of Food Science and Physiology, University of Navarra, Pamplona, Spain (författare)

Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight : a Big Mac challenge

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • 2014-05-20
  • Wiley,2014
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-63695
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63695URI
  • https://doi.org/10.1096/fj.14-250167DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:EU 222720 277713Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (SyMMyS) 250114Finnish Foundation for Cardiovascular ResearchDiabetes Research FoundationHelsinki University Central Hospital Research FundsAcademy of Finland grant 266286Carlos III Health Institute of the Spanish Ministry of Health
  • Postprandial responses to food are complex, involving both genetic and environmental factors. We studied postprandial responses to a Big Mac meal challenge in monozygotic co-twins highly discordant for body weight. This unique design allows assessment of the contribution of obesity, independent of genetic liability. Comprehensive metabolic profiling using 3 analytical platforms was applied to fasting and postprandial serum samples from 16 healthy monozygotic twin pairs discordant for weight (body mass index difference >3 kg/m(2)). Nine concordant monozygotic pairs were examined as control pairs. Fecal samples were analyzed to assess diversity of the major bacterial groups by using 5 different validated bacterial group specific denaturing gradient gel electrophoresis methods. No differences in fecal bacterial diversity were detected when comparing co-twins discordant for weight (ANOVA, P<0.05). We found that within-pair similarity is a dominant factor in the metabolic postprandial response, independent of acquired obesity. Branched chain amino acids were increased in heavier as compared with leaner co-twins in the fasting state, but their levels converged postprandially (paired t tests, FDR q<0.05). We also found that specific bacterial groups were associated with postprandial changes of specific metabolites. Our findings underline important roles of genetic and early life factors in the regulation of postprandial metabolite levels.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Maukonen, JohannaVTT Technical Research Centre of Finland, Espoo, Finland (författare)
  • Mattila, IsmoVTT Technical Research Centre of Finland, Espoo, Finland (författare)
  • Rissanen, AilaObesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland (författare)
  • Saarela, MariaVTT Technical Research Centre of Finland, Espoo, Finland (författare)
  • Kaprio, JaakkoDepartment of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland (författare)
  • Hakkarainen, AnttiDepartment of Medicine, Division of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland (författare)
  • Lundbom, JesperDepartment of Radiology, Hospital District of Helsinki and Uusimaa (HUS) Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland (författare)
  • Lundbom, NinaDepartment of Radiology, Hospital District of Helsinki and Uusimaa (HUS) Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland (författare)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark(Swepub:oru)tihn (författare)
  • Pietiläinen, Kirsi H.Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland (författare)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark(Swepub:oru)moc (författare)
  • VTT Technical Research Centre of Finland, Espoo, Finland; Department of Food Science and Physiology, University of Navarra, Pamplona, SpainVTT Technical Research Centre of Finland, Espoo, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The FASEB Journal: Wiley28:9, s. 4169-41790892-66381530-6860

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