Food deprivation increases bacterial translocation after non-lethal haemorrhage in rats

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:DiVA.org:oru-63856" > Food deprivation in...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Bark, TorKarolinska Institutet (author)

Food deprivation increases bacterial translocation after non-lethal haemorrhage in rats

Article/chapterEnglish1995

Publisher, publication year, extent ...

Taylor & Francis Scandinavia,1995
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:oru-63856
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63856URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:1956024URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

OBJECTIVE:To investigate whether brief fasting before the induction of hypotension by non-lethal haemorrhage may induce translocation of enteric bacteria to mesenteric lymph nodes or blood in rats.DESIGN:Laboratory experiment.SETTING:University departments of surgery and microbiology, Sweden.MATERIAL:39 Male Sprague-Dawley rats.INTERVENTIONS:20 animals were fasted for 24 hours, all 39 then underwent controlled haemorrhage for 60 minutes that reduced the blood pressure to 55 mm Hg.MAIN OUTCOME MEASURES:Differences in blood loss, blood glucose concentrations, and packed cell volume; and aerobic cultures of mesenteric lymph nodes and blood.RESULTS:Fasted rats (n = 20) lost 2.3% of blood volume compared with 2.8% in fed rats(p < 0.001). Packed cell volume dropped by 11.3% in fasted rats and 16.5% in fed rats (p < 0.001). Glucose concentrations rose by 7.0 mmol/l in fasted rats compared with 21.0 mmol/l in fed rats (p < 0.001). Mesenteric lymph nodes contained enteric bacteria in 14/20 fasted rats compared with 6/19 fed rats (p < 0.05). In 4 fasted rats blood cultures grew pathogenic bacteria compared with no fed rats (p = 0.11). The number of bacteria found in mesenteric lymph nodes was significantly greater in fasted than in fed rats (p = 0.01).CONCLUSIONS:Brief fasting before hypotension caused by non-lethal haemorrhage was associated with significantly increased bacterial translocation compared with fed animals. Increases in blood glucose concentrations and plasma refill may have had a protective effect in fed rats. These experiments may be of clinical relevance as elective operations are usually preceded by overnight fasting.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

Katouli, MohammadDepartment of Surgery, Karolinska Hospital, Stockholm, Sweden (author)
Svenberg, Torgny E.Department of Surgery, Karolinska Hospital, Stockholm, Sweden (author)
Ljungqvist, Olle,1954-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Karolinska Hospital, Stockholm, Sweden(Swepub:oru)olt (author)
Karolinska InstitutetDepartment of Surgery, Karolinska Hospital, Stockholm, Sweden (creator_code:org_t)

Related titles

In:European Journal of Surgery: Taylor & Francis Scandinavia161:2, s. 67-711102-41511741-9271

Internet link

Find in a library

European Journal of Surgery (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Bark, Tor; Katouli, Mohamma ...; Svenberg, Torgny ...; Ljungqvist, Olle ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

Articles in the publication: European Journal ...

By the university: Örebro University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se